ID A0A174U6P6_9BACE Unreviewed; 604 AA.
AC A0A174U6P6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Mismatch repair ATPase (MutS family) {ECO:0000313|EMBL:CUQ18254.1};
GN Name=mutS_3 {ECO:0000313|EMBL:CUQ18254.1};
GN ORFNames=ERS852494_04221 {ECO:0000313|EMBL:CUQ18254.1}, F2Y31_15990
GN {ECO:0000313|EMBL:KAA5496869.1}, F2Y39_09745
GN {ECO:0000313|EMBL:KAA5477873.1};
OS Bacteroides caccae.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=47678 {ECO:0000313|EMBL:CUQ18254.1, ECO:0000313|Proteomes:UP000095657};
RN [1] {ECO:0000313|EMBL:CUQ18254.1, ECO:0000313|Proteomes:UP000095657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2789STDY5834880 {ECO:0000313|EMBL:CUQ18254.1,
RC ECO:0000313|Proteomes:UP000095657};
RG Pathogen Informatics;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000368418, ECO:0000313|Proteomes:UP000427825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A19 {ECO:0000313|EMBL:KAA5496869.1,
RC ECO:0000313|Proteomes:UP000368418}, and BIOML-A25
RC {ECO:0000313|EMBL:KAA5477873.1, ECO:0000313|Proteomes:UP000427825};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
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DR EMBL; CZAI01000014; CUQ18254.1; -; Genomic_DNA.
DR EMBL; VVYJ01000004; KAA5477873.1; -; Genomic_DNA.
DR EMBL; VVYD01000016; KAA5496869.1; -; Genomic_DNA.
DR RefSeq; WP_055173713.1; NZ_VVYK01000015.1.
DR STRING; 47678.ERS852494_04221; -.
DR Proteomes; UP000095657; Unassembled WGS sequence.
DR Proteomes; UP000368418; Unassembled WGS sequence.
DR Proteomes; UP000427825; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03283; ABC_MutS-like; 1.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF99; DNA MISMATCH REPAIR PROTEIN-RELATED; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000095657};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..411
FT /note="DNA mismatch repair protein MutS core"
FT /evidence="ECO:0000259|SMART:SM00533"
FT DOMAIN 424..604
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT COILED 1..28
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 295..326
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 604 AA; 69685 MW; 55F60AB42319D4BB CRC64;
MEKLENIIST YQQIIQESEQ ALQRARKRIY YISLLRLVLF VEAIAAAFIF WSDGWLSLFV
FAILPFISFI WLVKRHNLWF YRKDYLKKKI EINEQELRAI QYDFSDFDSG NEYIDPAHLY
TYDLDVFGDY SLFQYINRTS TPVGKQHLAD WFNAHLELKE SIEQRQEAIR ELSTDLEYRQ
QIRLFGLLYK GKPADTNEIR EWAGSPSYYR KHTLLRIIPT VVSIINLICI GSAIVGILPA
TVPGGVFFCF VIFSSIFSKG ITKLQATYGK KLQILSTYAD QILLTEKKEM NSPVLQQLKT
ELTSQNQTAS QAVRQLSKLM NALDQRSNLL MSTILNGLIF WELRQVMRIE KWKETHASDL
PRWIETIGEI DAYCSLATFT YNHPDYIFPK ISSQSFHLRA EALGHPLMNR NKCVRNGIDI
DKRPFFIIIT GANMAGKSTY LRTVGINYLL ACIGAPVWAK QMEIYPARLV TSLRTSDSLT
DNESYFFAEL KRLKLIIDKL EAGEELFIIL DEILKGTNSM DKQKGSFALI KQFMNMNTNG
IIATHDLLLG TLIESFPQNI RNYCFEADIT NNELTFSYQM RNGVAQNMNA CFLMKKMGIA
VIDD
//
