ID A0A175AGZ1_CLOIN Unreviewed; 536 AA.
AC A0A175AGZ1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:MZH62497.1};
GN ORFNames=GT649_21480 {ECO:0000313|EMBL:MZH62497.1};
OS Clostridium innocuum.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Coprobacillaceae; Thomasclavelia.
OX NCBI_TaxID=1522 {ECO:0000313|EMBL:MZH62497.1, ECO:0000313|Proteomes:UP000478871};
RN [1] {ECO:0000313|EMBL:MZH62497.1, ECO:0000313|Proteomes:UP000478871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIOML-A13 {ECO:0000313|EMBL:MZH62497.1,
RC ECO:0000313|Proteomes:UP000478871};
RX PubMed=31477907; DOI=.1038/s41591-019-0559-3;
RA Poyet M., Groussin M., Gibbons S.M., Avila-Pacheco J., Jiang X.,
RA Kearney S.M., Perrotta A.R., Berdy B., Zhao S., Lieberman T.D.,
RA Swanson P.K., Smith M., Roesemann S., Alexander J.E., Rich S.A., Livny J.,
RA Vlamakis H., Clish C., Bullock K., Deik A., Scott J., Pierce K.A.,
RA Xavier R.J., Alm E.J.;
RT "A library of human gut bacterial isolates paired with longitudinal
RT multiomics data enables mechanistic microbiome research.";
RL Nat. Med. 25:1442-1452(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MZH62497.1}.
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DR EMBL; WWTM01000068; MZH62497.1; -; Genomic_DNA.
DR RefSeq; WP_008817561.1; NZ_WWTY01000069.1.
DR AlphaFoldDB; A0A175AGZ1; -.
DR Proteomes; UP000478871; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR029151; Sensor-like_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF30; DIGUANYLATE CYCLASE DGCZ; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..535
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT COILED 222..252
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 536 AA; 61594 MW; AF5DB86A5952ECEA CRC64;
MKRSLFKKHQ LWYVAGFLII NLAACIIIGN HAYRQIQADM NAHALQSQEE VQSVMDDYRH
SFQLFTTMLE REVEAEPKPA VIWKYLKKLD KQLQAIEGDT FDGLYMYYRN SYLYSWDTPF
EQYEKSGYDA TTCPWYRNAV DAKGEIVFTP PYMSFANHYI LSTISQLQPD QKTVFAYDIK
MGNIQKLIAS LQAYDKEQLI IFDKKGTIIG STEEDYLGGN LMQSTEENRE QLTEANNKLK
QADSSISKED RKKLEDEASY AQAFYDFQNS FSTDFNSLLK DDGMQLVDYQ NQKYFGLIQQ
GNEFDYLILV PVYSMLSATL QIWLIPLLIL EIILIYVLSQ ISRELKNREL KGAYVELGQT
QKRLEIALQA AQKAAAIDEL TGMMNMKSFR STVKHHIQGM EEDENGILIM IDGDHFKSVN
DQYGHSAGDE VIRLTAQMIV GRIRTVDYAS RLHGDEFAIF VSNTRDYRVA EKIMEDINLS
LAKEAQKRNM PAITLSSGAI IACPNDNYME LIKAADEALY RAKETHNGAF RQAEER
//
