ID   A0A175VQ92_9PEZI        Unreviewed;       696 AA.
AC   A0A175VQ92;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Methylenetetrahydrofolate reductase 2 {ECO:0000313|EMBL:KXX73220.1};
GN   ORFNames=MMYC01_205129 {ECO:0000313|EMBL:KXX78925.1}, MMYC01_210073
GN   {ECO:0000313|EMBL:KXX73220.1};
OS   Madurella mycetomatis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariales incertae sedis; Madurella.
OX   NCBI_TaxID=100816 {ECO:0000313|EMBL:KXX73220.1, ECO:0000313|Proteomes:UP000078237};
RN   [1] {ECO:0000313|Proteomes:UP000078237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA   van de Sande W.W.J.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KXX73220.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mm55 {ECO:0000313|EMBL:KXX73220.1};
RA   Hoefler B.C., Straight P.D.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KXX73220.1, ECO:0000313|Proteomes:UP000078237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237}, and Mm55
RC   {ECO:0000313|EMBL:KXX73220.1};
RA   Van De Sande W.;
RT   "Madurella mycetomatis genome sequencing.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXX73220.1}.
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DR   EMBL; LCTW02000513; KXX73220.1; -; Genomic_DNA.
DR   EMBL; LCTW02000103; KXX78925.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A175VQ92; -.
DR   STRING; 100816.A0A175VQ92; -.
DR   VEuPathDB; FungiDB:MMYC01_205129; -.
DR   VEuPathDB; FungiDB:MMYC01_210073; -.
DR   OrthoDB; 1381745at2759; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000078237; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078237}.
SQ   SEQUENCE   696 AA;  77939 MW;  AF36CADE1F715BAF CRC64;
     MGEILPSLEL PVEAPKDHTM DKITDKIAAL PADTNYFSLE FFPPKTAMGF SNLRDRLDRM
     ARALRPLFVN VTWGAGGSTA TKSLELAEIC QRELGLTTCL HLTCTNMSRR MIDKALDDAK
     ALGIRNILAL RGDPPRRAEY RDTNEPEPED EEEFAWAVDL VRYIRKTHGD YFCIGVAAYP
     EGHADESHPL GQSLEHDLPY LVEKTQAGAD FIMTQLFFDI EAYKRFEQTL RDHPSGAFKD
     IVIVPGLMPI QSYQMIKRTT KLSHAKIPAP LMARLDAVKG DDEKVKEVGV DIISEIVEQI
     REIKSRTKGP RGFHFYTLNL EKAVSFIVER TGLISPSTPE EEEAVITQDP LPDIKFLRVN
     GSTPDQSSYG PMRRKASIGS DPRDRVIVQG RPPSYPDWEA TALEASVPAE PINTRANTLA
     ISEGEGVLGR EATWDDFPNG RWGDARSPAY GQIDGYGVSL HVTVAQARQL WGTPRTTEDV
     NNIFIRHLRG ELSTIPWSEE SFSPETEKIR NQLIALNSKG WWTLASQPAV NGLRSSDPTF
     GWGPQNGFVF QKAFVEFFLP SADWRALERR LARPEMKDVV CFYATNAAGD FVSSDTAARA
     SSADADGEPY REASTNAVTW GVFPGKEIVT PTIIEEVSFR AWSEEAFGIW GEWAKIYPKG
     SESEKFLEKV RGDLWLVNII HHEFVESDAL WELLLT
//