ID A0A175VVP4_9PEZI Unreviewed; 1552 AA.
AC A0A175VVP4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=MMYC01_207737 {ECO:0000313|EMBL:KXX75608.1};
OS Madurella mycetomatis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariales incertae sedis; Madurella.
OX NCBI_TaxID=100816 {ECO:0000313|EMBL:KXX75608.1, ECO:0000313|Proteomes:UP000078237};
RN [1] {ECO:0000313|Proteomes:UP000078237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA van de Sande W.W.J.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KXX75608.1, ECO:0000313|Proteomes:UP000078237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA Van De Sande W.;
RT "Madurella mycetomatis genome sequencing.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXX75608.1}.
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DR EMBL; LCTW02000259; KXX75608.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A175VVP4; -.
DR STRING; 100816.A0A175VVP4; -.
DR VEuPathDB; FungiDB:MMYC01_207737; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000078237; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02736; RNAP_III_Rpc1_C; 1.
DR CDD; cd02583; RNAP_III_RPC1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR035698; RNAP_III_Rpc1_C.
DR InterPro; IPR035697; RNAP_III_RPC1_N.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000078237};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 269..573
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1552 AA; 174270 MW; 2C89EB5B27770192 CRC64;
MANDAIEAPE RRRVRRKEQL VDQLPKRFKA LKFGIQSHQD IVSQGVLEVS DNLLYDVENR
RTPFPHGPLD PRLGTSSTNR ESKCSTCQLG LQDCPGHFGH VRLPLPVFHI GYLKYIQATL
QNICKECSRV LLTEDERRQF LKELRRPGID NLRRSAILKR INEQCRKVKN CYSCGSLQGV
IRKLSVMKLV HDKFAAYNKS TAQKKIPPES KIEFDASFAH AKRYTPELEK HYRKAMDDLN
PLKVLNLFKA ISPLDCELLG LDPSEGRPEM FLWQYVPAPP ICIRPSVAQE NASNEDDITS
KLSEIILYAG HLRESLKKGV ALPVIMEQWE FLQLQVGMYV NSDVPGLYQP GFGKPIRGFC
QRLKGKQGRF RGNLSGKRVD FSGRTVISPD PNLSIEQVAV PQLVAKNLTY PERVNFANIE
KLRERVKNGP NIWPGAQGII KKDGAKYNLK IGSETLRERH ANDLAFGDVV ERHLEDNDIV
LFNRQPSLHK LSIMSHFVKV RPWRTFRLNE CVCTPYNADF DGDEMNLHVP QTEEARAEAI
NLMGVKHNLI TPKNGEPIIA ATQDFITAAY LLSDKELFFD RDTFTHICTQ MLLGETYLDL
PPPAIIKPKA LWTGKQIFNV LMRPNKESPV LVNLDAKNKI FSKKKDGQIP DMDIDDAFLV
VRNSEVMCGR MDKSTVGGGK KNSVFYVILR DFGPDYAAAA MNRLAKLCAR TLSLWGFSIG
VGDVWPSGPL TEHKAKLVSD AYKTCDDLIE TYRQGKLEKA PGCNLEQTLE NSVSGILSKV
RQQAGNYCVD NLSKNNAPLV MARSGSKGSD INVAQMVACV GQQIIGGKRV PDGFQDRSLP
HFHKNARQPP SKGFVRNSFY TGLVPTEFLF HAISGREGLV DTAVKTAETG YMSRRLMKSL
EDLSTQYDDT VRTSEGGIVQ FQYGADRLDP VDMEGDAKPV DFARTWNHAQ SITWSNSDAS
LLPREIQELS KTMLDEERKK YVRRHLVTNE VLDYDDERIR NGKDHDVFIA IDEHESARVY
LNTIRDYIAE HATKLARARK AVGLDPCIPA DDDRMKKAVD EWKPATKVSS SEMEIDAFGK
PRKSFEYALR ELRRELDGVD GLDEDARQER AQVMAQAHVD RVAKVSERTL RQFIQMCLHK
YKRARVEPGH AVGAVGAQSI GEPGTQMTLK TFHFAGVAGM SITQGVPRIK EIINASKLIS
TPVITCELEN KVDIKAARIV KGRIEKTYIS DVVSYIDDEW LPDVAKITLQ VDMQVLSDMQ
LGITMKDIAD AIVRAKKLKL KVEPEDLRVG GDRVEVIIRN TWQDATAARK AAKVRATAIE
KGQAVSTVMD ESAADFQLRV NFLKRMLPQV VISGYPEASR AIIQTSEQNE HKVLVEGYGL
RACMTTEGVV GTKCVSNSVM ECRDVLGIEA ARTTIAKEIE SVMSYLGIDP RHMELLADVM
TYKGEILGIT RFGMAKMRDS VLQLASFEKT PDHLFDAAAG MKKDRIQGVS ECIIMGQSMS
IGTGAFEVVR RLGIRDHQVV PKPTVFEDAW RKQEATTRKA RMEKRRSGIA VA
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