ID   A0A175W8T4_9PEZI        Unreviewed;       350 AA.
AC   A0A175W8T4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=NADP-dependent alkenal double bond reductase P2 {ECO:0000313|EMBL:KXX79889.1};
GN   ORFNames=MMYC01_203768 {ECO:0000313|EMBL:KXX79889.1};
OS   Madurella mycetomatis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariales incertae sedis; Madurella.
OX   NCBI_TaxID=100816 {ECO:0000313|EMBL:KXX79889.1, ECO:0000313|Proteomes:UP000078237};
RN   [1] {ECO:0000313|Proteomes:UP000078237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA   van de Sande W.W.J.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KXX79889.1, ECO:0000313|Proteomes:UP000078237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA   Van De Sande W.;
RT   "Madurella mycetomatis genome sequencing.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXX79889.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LCTW02000074; KXX79889.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A175W8T4; -.
DR   VEuPathDB; FungiDB:MMYC01_203768; -.
DR   OrthoDB; 179761at2759; -.
DR   Proteomes; UP000078237; Unassembled WGS sequence.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05288; PGDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078237}.
FT   DOMAIN          86..345
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   350 AA;  38550 MW;  72B7E83660B3FBAC CRC64;
     MHSNKTLIFK KVPTGFPIPG EHLAVEDRPI DISSVPSGGV TLSILYASFD PYLRGKMRPS
     HIKSFTPAFE LGSPIQNDTV ARVLQSDTDA YKPGDLLIAS LPLAEYAVLG KDDLGQIRSK
     VHNRHGLKDL GLFLGPLGMP GMTAWSSLYE IGQPKKGETI FISSAAGAVG QIVGQIAKRE
     GLRVVGSVGS DEKLEFIVKE LGFDGGFNYK KERTRDALKR LAPEGLDIYY DNVGAEQLAD
     ALDAMNDFGK IVACGMIANS NVPEEERYGV RNLYNIVRKR LTMRGFIVYD HGFWDKYEQD
     HQEKMQQWLA EGSIQAKLDV TEGIDNAAEG LVKLFWGGNF GKAVLKIKEE
//