ID   A0A175W9P4_9PEZI        Unreviewed;       299 AA.
AC   A0A175W9P4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:KXX80315.1};
GN   ORFNames=MMYC01_201320 {ECO:0000313|EMBL:KXX82364.1}, MMYC01_203364
GN   {ECO:0000313|EMBL:KXX80315.1};
OS   Madurella mycetomatis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariales incertae sedis; Madurella.
OX   NCBI_TaxID=100816 {ECO:0000313|EMBL:KXX80315.1, ECO:0000313|Proteomes:UP000078237};
RN   [1] {ECO:0000313|Proteomes:UP000078237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA   van de Sande W.W.J.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KXX80315.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mm55 {ECO:0000313|EMBL:KXX80315.1};
RA   Hoefler B.C., Straight P.D.;
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KXX80315.1, ECO:0000313|Proteomes:UP000078237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237}, and Mm55
RC   {ECO:0000313|EMBL:KXX80315.1};
RA   Van De Sande W.;
RT   "Madurella mycetomatis genome sequencing.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXX80315.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LCTW02000063; KXX80315.1; -; Genomic_DNA.
DR   EMBL; LCTW02000016; KXX82364.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A175W9P4; -.
DR   STRING; 100816.A0A175W9P4; -.
DR   VEuPathDB; FungiDB:MMYC01_201320; -.
DR   VEuPathDB; FungiDB:MMYC01_203364; -.
DR   OrthoDB; 517134at2759; -.
DR   Proteomes; UP000078237; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR005645; FSH-like_dom.
DR   PANTHER; PTHR48070; ESTERASE OVCA2; 1.
DR   PANTHER; PTHR48070:SF6; ESTERASE OVCA2; 1.
DR   Pfam; PF03959; FSH1; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000078237}.
FT   DOMAIN          34..281
FT                   /note="Serine hydrolase"
FT                   /evidence="ECO:0000259|Pfam:PF03959"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  32691 MW;  1287D5A575B267E8 CRC64;
     MGDNRDTPQP PSRTDSLSVR TAANSKNTNT KAKKEVRILM LHGYTQSGPL FRAKTRALEK
     LLAKALGPLN MMPTLLYPTA PNRLSPRDIP GYEPSGGSSE SGEVEVMDSW AWFRKDEASG
     TYRFVEEGMR RLAEAVTELR GGGSDDADRA EGDECFIDGV IGFSQGGCMA AMLASAMEGN
     HEPTAVGAAK EHEGWVNAVR EANGGRPLKF AVIYSGFYAV PEDLRWLYEP KVRTPTLHFL
     GSLDTVVDES RSQGLVERCE EPIVMVHPGG HYVPVSKEWV MPLAGFIRKY LEGPTGEAN
//