ID A0A175WBA1_9PEZI Unreviewed; 5065 AA.
AC A0A175WBA1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Nonribosomal peptide synthetase 8 {ECO:0000313|EMBL:KXX80751.1};
GN ORFNames=MMYC01_203926 {ECO:0000313|EMBL:KXX80751.1};
OS Madurella mycetomatis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariales incertae sedis; Madurella.
OX NCBI_TaxID=100816 {ECO:0000313|EMBL:KXX80751.1, ECO:0000313|Proteomes:UP000078237};
RN [1] {ECO:0000313|Proteomes:UP000078237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA van de Sande W.W.J.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KXX80751.1, ECO:0000313|Proteomes:UP000078237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA Van De Sande W.;
RT "Madurella mycetomatis genome sequencing.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXX80751.1}.
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DR EMBL; LCTW02000051; KXX80751.1; -; Genomic_DNA.
DR STRING; 100816.A0A175WBA1; -.
DR VEuPathDB; FungiDB:MMYC01_203926; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000078237; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 3.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 13.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000078237}.
FT DOMAIN 753..829
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2304..2381
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3839..3915
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4407..4483
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5065 AA; 559169 MW; BEFEE82D861E456E CRC64;
MDERQPQMPG PNDEPGNEAA SGGIPRTDPF RTVQTLLCVL PARVARTPVP VRILLDFKES
VRTLLDRVQL QSFDMLEFEQ YGLQNIKKSA PTAAAACDFQ SLLVVHHDAG AKKPENEFTW
SSERSVADFL TNALTLECQP SGSRLTLTAS YDSSIMDERQ MSRMLATFEH ILQQICEGEQ
NKTLRLQDID TISPSDRAEI ALITRQLPPI VYDRVHDMFA RQAAAAPNAV AVSAWDGDFT
YSELDNLSTK LARHLRSLGI GPECFAPFAF EKSKWVPVSQ LAILKAGGAC VPLDPSQPVD
RLQSIVSTLD AKVILTSSVH SNLLTSCNGI KNFVVVSQEA LDRLPEQGGP AINPQTSPSS
PCYAIFTSGS TGTPKGVVWE HATLCTSMTE HGAAFNYSTS SRVLQFSSHT FDVSVSELLT
TLIFGGCVCI PDDFTRLNGI SQFMNEKRVN WAFFAPSFAR LMDPATIPTL RTIVLGGEAP
GKDNIERWSG RPNLELIVTY GPAESCIYCA KNSVSGPQID GSIGHSIGGM MWVADLGRPS
ELAPIGAVGE IVVEGSILAR GYLKDPAKTS ASFRPMPAKW ANGRSSRVYY TGDLGCVNTD
GTISCLGRKD DQVKIRGQRV ELPDIEYHLR KDERVRQALV LYPRSGPCAD HLIGILSMVQ
DKPTTGPASS TAITIANAND WAWVPDVQER LSQKVPVYMI PAIWIVLKSI PLMPASQKVN
RKMVSEWTKH MDQSIYEHIA GLSAGSSSED IPTMASPLEE HVRAIWSEIL NVGRHKIGPN
ASFLRLGGDS ISAMQVVTRC RNEGINVTVQ DILKAKTISE FCKRAAASAT TQNISSDLVE
DEAESGAPFA LSPIQKWFLA LAPTAPNYFN QSHLLRFTDK VDFNKLQCAL IIIIKRHPML
RARFHEVDGD WQQYISTDAG GSLQCRQFES VWTIQKAIER ASEAQNNLDI TAGPLMAADM
YQMADGASVL FITCHHLVID LVSWRVVLQE LEDILRTGKL VGVQQPLSFR TWCRLLQERA
GSVVDSCEIP PQDFEFWGVT STENTAAQVT HRGFSLDDQT TELLMGRSND AFNTEPLDLL
VTAVAHSFNE IFRSIRGPVA IFNEGHGRDT WRPDVDVSST VGWFTSMCPI LLSDHGGDVL
RSLKEVKDVR RRIPEKGLSF FTSFAQNTTS AVEITFNYFG LYQQLERQGA LFNRMSWAPF
HAPPDSAPDV PRFSIFDVSA GVENGVLSMD FAFNSGVKHQ HLVQQWIEAC LEALRDIIHA
TIKQEEASLT LADLPNLHVG YDELSTLLES TLPKAGVMVS NVQDIYPCSP MQTALLVSQA
VDPTLYAVRY VWEVVSKSAK PVSADKLIMA WKQVVKQHPM LRTVFVETTS SADGKSVSTY
TQVVLKDFEP NVLVCEDATV FPLGRPEHHI SNGPPYQLVL SQQGSGKLLV QLDISHTLID
GSSINLLLDH IVKAYDGVHL ASVNSEDAYS NYIGYLDKQD LDSSRQFWKS YLSGTEPCHF
PTLNPAAPGH IRKLEYLDFN YPDHARLHSV CAEAETTAAS VYKLAWALLL RAYTGNNSPC
FGYLASGRDL PIQGIEEAVG PFINMLVCMI SLESDDTQVE AILKVAHADY ANCLSHQLCS
LAEIQRSLGL GGDRLFNTVM SVQRLLPPGT SASTVEFQPV HVEDPSEFDI ALNIGDSPDF
VDISLTYNSD VLSTKQAKRL ASTFNLAIDG ILDSITKPLR NVNLLTPGDL QKIVEWNGSA
TSTAVQAQCD QLINLHLSSR ANAPAISGWD LSATYSELDA FASTVARHLV SKYSVAPNTL
VPFCFEKSSW AIIAMLGIMK AGAAFVPLDP KHPIDRLASI AQRVQAPLVV CSEQNEHIGQ
ELGGNLSIPY LLVGSCSMEA LKGSTVNKGS LASLSQTRSP LDLAYCLFTS GSTGTPKGVL
IQHEALCSGS TIHGKAFNYT AHARTLQFAS YGFDACITEI FTTLVMGGCV CVPSEAQRMD
KDKLMDFINE QDVNHVLLTP SVLSLLDPFK VPSITTLLLG GEAAGYQLIN KWRAPHRRVL
IAYGPTECTV ICAGHDVTDP DSLQPGKSSI GNSIGSIAWI GDIGDYNKLV PIGSIGELLV
EGPILARGYL GDEVKTSAAF VKPTWAGSQR RVYRTGDLVR YQEHGTMEYL GRRDNQVKLR
GQRLELGEIE EQMAKQSPVQ QCAVLLMREG LFANKLAAVM TLKASDSTTK IAGRLTLGSD
SDEGLDVLAG KDVSSAISLV SQALTEVLPS FMVPTCWIVV DQLPLMASGK TDRRFLTSCI
DRITQEMYQL CTGTSGEENS ADGESLTTVE KTIRQVWSAV LNVPERSINP STGSFIKMGG
DSISAMEAVA HCRENGIPLL IEQLLKAKSI KQLAANFEGL DLVPATADTA STTDAQKIAP
ETQEVDGDQS EDNITMFGLS PIQRMFTRLS PGENHFNQSF LLKASGSKAR LDEENIRKAL
DVIVRRHAML RARFQKLGRS FKQWIEPVVE DSYVFQSWDI QEETFFPTEA AERIRETQQS
LDIENGPVFA GDLFSIGDEQ YVFLTAHHLV IDLVSWRVIL KDLEDFLVTG SISTYRSMSF
EKWCGLLSTH RKSLVGTTTI PFKVPSQDYK YWGMAGKPNY ASDFEHRQFT LPEGISESLL
GSCNDAFGTE ALDLFISAVM HSFAATFQDR DIPPIYNEGH GREPWDDSID LSRTVGWFTT
IAPVWVDSRC CNKDILEYIK QVKEARRNTP HKGFSYFSSL DLERKPFSIE VSFNYFGSFQ
QLDRDDSLLK QIHWRNIDVD PCEVSGKHKK FSLIDINAES EKGQLVFTFS FNSNISRRED
INRWIGNYQK SLEHMARVLG SRTVDGLSST LAAPQSTQNP VYKALGIEDT NVEDIYPCTP
SQQGMLLSQS KDPEMYWFRS VYELESTTMS ISFEKLRQAW KTVVKRHPVL RTIFIEQNST
DGLYDQLVLR DYEPEVIEFQ VSASMRGDEL IESLKIQSIP SDMVNRRTPQ HQLRIARQAS
TGRVFCSFLL SHAIADGGSM GVILKDFGLA CEARSLSATK PLLRSYIHYI QSRDTAKDIN
FWKKSLDSTD PCFLPTEESL QSDRVLHKAE VPIDKINYAK MLGVARELGV SAFTLLQVTW
ALTLREYVNA DRDECCFGIV TSGRDLPIQE IGDIVGPLVN ILVSRVALPH EQPISQIAEA
VHDNFIDSLA HQTSSLAQIT HELGSGTLFN TGMTMQKAAA AVSETVEGAA FRPMGGQDPT
ENTQFDLVVQ ALDDGQRLRA HMSYWCNKIS DNRANDMAIT FASILSQIIQ NPDIRPIDLQ
VVSEKDVEQL WAWNSSLPKT LDIRIEEMIA QRTIEYPERD ALWSTEEVLS YQQLELFSSR
VAQGFLADID REEVVPLCFE KSIWVVVAML AVLKAGGTIV LMDPSHPLER LRCITDTVKA
KRILASPTQA DLCLNRLGLP TVVISRDMFK RRSGLPGTTA RSAMAKRTVT SSADAAYVVF
TSGSTGTPKG SVTEHRSFCT ATQGYHQAIG QLPGERVLQF ASYSFDASFL EILGSLMVGA
TVCVPTDKER SNKLASFINK SRTTFAVITP TVASLLEPED VPTLSCLALC GEPMTVSHIT
TWSTKVRLVN AFGPSECCVG SAANSLVTSE SSPKCIGKAV SCCYWVVHPR NHNRLARIGS
IGELLIEGPI LARHYLNEPV KTKAAFISNP DWARPGRGTR LYKTGDLVYQ NPDGSFQYVG
RKDTQAKIRG QRLEFGDIEQ AFREVVPETE NVVAEIVQAE GQSPKLVVFF SAKNIGHGDV
DVTALQAKMA LKIPAYMVPS TIVPMDKMPL MPSGKIDRKK IKTLGANLPT RQEKRIGRLP
TADMEVALAD LWREVMRSAP TQIMSDDSFF HVGGDSYTAM KLVTAARARG IALSVTAIMQ
TPKLADMARK ANHVANAGQP AIELEITLPF SMIEWAPEVE DEVSRQCDIP IGSIEDVYPC
TPLQEGLFVL SVKQVGAYVA RHCYQLPHGL DLARYKRAWN TVYESSAILR THIVQLDNTG
GRKQSGLYQV VVKKPLVWQR ATSLDGFTTT PRVTLGAPLA EFAIVEESTG LRYLILTMHH
AAYDAASLRM LLEDVENIYE GEELTLRPPF REFIKQLWST ELHQTRDFWS QYLDNTRPAV
FPSIPSGYVP SADSTIDSEL TLPELKSKTH TASTMIRVAW AIVLAQHAKT NDVVFGETLS
GRNGSDGAVT EVEGPMITTV PVRCTFDDNA IIQHILSSMQ NSMVDMIPYQ HAGLQTIRAA
SPSAAAACNF GCLVTIAPES SAPANPGLGI VPVDVGAPPA MSYPLSVQFI IGEEGKMKVS
VCYDHRLVES MQVRRMVDQF VGVLGQLCDG RKQVVGEIEV EGNDLAIANA SLRSNALGVL
QGEIEDLLED ISSQELSKPD SCSDVTRTRG DLEQEMKRLW ADILTIQPGE ITPTDNFFQL
GGDSISAMRL VTAAERKQIK ITVADIFQHP TFEGLCEFAA QANALDQQEI AVGEPGFQQD
YEAFAVVDFL ELEREDVLEA VCRQLSVFPG DVEDVYPATD YQAWAISHGL MRSRGNTNYF
LFRLHGDLDT FRLEQACRKM VASNPILRTL FTTIRGEVMQ VVLRSYQIEF LRYGSEHYAD
DTFIRWLVEQ DTQRSAYLSQ SIVRFKLVLH ADGHYVLIMR MSHAQYDGMS LPLLTQDLEK
CYNGQEPKQR PSFGKFIQGA TFSEETAINF WSHLLDGSSI TEIVEHSGPS HKHNVDTIRT
RTLPPIPAKV AGMSQATLVK AAWALVLAKM SGQRDIVFGN LVFGRNLPVS GIEDIAGPCI
NIIPVRVKVD AMDSIHNLLA LVQEQQMAAM PHESLGFRRL IKNCTDWPHW TRFSSVVQHQ
QLGRDGAQGQ EFSLAENLRC EMGVLGPAYD SADLWVQTTP HMDSFKVEIG SCSSVVQPMV
AETLLDKLCA TLSIFSSISA GASPHLWELL ARDGPPLIPI KSSLVEQVWS KVLPDADTIA
WDTPYFDVWG DEIAPYWYVD SGRFRAGEEG NWAIISLPHV FLIAQPGVVR IIGLRADFVR
LGRCIMDKGK DEPAQSAFDT RVTCE
//
