ID A0A175WJ59_9PEZI Unreviewed; 2655 AA.
AC A0A175WJ59;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Lovastatin diketide synthase LovF {ECO:0000313|EMBL:KXX82904.1};
GN ORFNames=MMYC01_200634 {ECO:0000313|EMBL:KXX82904.1};
OS Madurella mycetomatis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariales incertae sedis; Madurella.
OX NCBI_TaxID=100816 {ECO:0000313|EMBL:KXX82904.1, ECO:0000313|Proteomes:UP000078237};
RN [1] {ECO:0000313|Proteomes:UP000078237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA van de Sande W.W.J.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KXX82904.1, ECO:0000313|Proteomes:UP000078237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mm55 {ECO:0000313|Proteomes:UP000078237};
RA Van De Sande W.;
RT "Madurella mycetomatis genome sequencing.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXX82904.1}.
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DR EMBL; LCTW02000006; KXX82904.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A175WJ59; -.
DR STRING; 100816.A0A175WJ59; -.
DR VEuPathDB; FungiDB:MMYC01_200634; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000078237; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF50; HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000078237};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..434
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2572..2650
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 453..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2451..2470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2655 AA; 286136 MW; B3EF5410F6F131D8 CRC64;
MSSQPDQHEP VAVVGMGCRW PGGAHDTSKF WEFLCDKVDG WKEFDDPRFS ARAFHHPNAD
RPGGFAMKGA FLAEQDARLF DHSFFGMTSL EVETMDPSQR KLLEVTYEAI ENAGETLESV
SGSRTGVFVG NFCLDHWMIQ SRDWDNPRPY AFVGAGTSIL ANRISYIFNL QGPSLTIDTA
CSSSMYALHL AVNAIRAGDC DSAIVAAANW IADPGVQIAL DKLGALSASS RCHTFDARAE
GYARGEGYGA IYLKRPSVAI AHNSPIRAMI RGSAVNSNGR TGGITRPSAS GQEAVIREAY
RHAGGLDFHD TSYFECHGTG TYVGDPIEVA AVGRVFASVR AAEDPLLVGS VKSNLGHGEG
ASALASVMKV VLALENGAIP PIFNLETPNP NIDFDAAKVK PVTEVTPWPA GRLQRASINS
FGYGGANAHC IIDHVNNVLP DYVAPGVYKS TRANGATNGH ANGHTNGHTN GHTNGHTNGH
TSGHTNGHIN GHAVGETNGH ANGQQSGNPN GKSLQHHPIV KSPQLTATPE AATRKLVLLP
LSAHNEKSLR LNFEALSKAI DDVSLADVAY TLGARRSRFA QRSFCIVDKD SIHETLVLER
KPVRAPLQAS NLGFIFTGQG AQWHSMGVEL FEYRVFRTAI EYLDYVLTML PNPPSWSLRS
ILSGDCDAAF IHKAEISQAV CTAVQVGIVD LLASWSIRPS GVAGHSSGEI AAAYAAGRIT
AAEAIVAAYL RGQAVSRNDR NGSMLAVGLG PDAVVQYVRG REDRVKVAAI NSPGSVTLSG
EEDTIDEVSA ALTADSVFNR KLKTGGNAYH SHHMLPIGAD YVEMLRQGNE RIQELGLANP
EHRYPHTLWV SSVTPSKATI EMDLASYWRA NLESPVRFSE AVTGLVGSED VPIHALVEIG
PHPALKSPIE QILKAVGKAV AYSSTLKRQE DARASLLQLA GALFSLNATV DLAAVNAVDD
TDSAGLTHGC TCTKLPPYQY TYGGLNYYES RASKEYRYRS ILRHDLLGSK VAGNAKLRPQ
WRNLLRMKDV PWLGDHRLVP DAVLPGAGYL AMAIEAAARI YHEFPEPLKI KGFSLRNVAI
KNSLVVPEDD YGIEVLTSME LADVATANSP AWATFSISSV GRETNEWTEH CTGSIKVELV
DDDERKRVEQ VPTAPRLVDT RRWYRKFLEV GLGYGPAFQP LSDIHADPTS NVAVATVDLH
TTSLKGGESR YPLHPASLDG AIQLGLIACH GGSSDEATTA FVPVQLSRLY LSNDIDEIAG
DKCTVIARGE RRGVRGAHLD LKMLSAKGDV LLHADGLRCI SYSSAAKPAD RSFSSPFTRL
VWKPDIRALS SRQARRLYPP PKSNVERAPA WGITNKLAHF VVLSMYQGLG KLRNSGHKPS
GDVGHFFDWI ERKGQRDNSG LMNEARELAS KGILLQKIEE LANQAQDIME VKIAKLLHDN
MADIFMERRT GMDVIISEDL LTPLYKSGLL MTGIYPQLHH ILASVAHSNP HLRILEIGGG
TGGATRIAMK AFNGPNGIKA YRDYTFTDIS AGFLSAARET LADFRDMNFS VFDIEGDPVD
QGYVEQTYDL IIACQVLHAT SNMHRTLTNC RRLLKPGGRL VLVETNQNFI VPGVVVGTFT
GYWAGIPDGR VDAPFQSLPS WDRSLREAGF SGLDVVLDDF PEPHNTTSVI LSTVPPEAAA
EASSATVHVL HSGKAAAPAL VEQIGKELHQ RGVTAKAATF DEAAESLTPE SRVVAFFDDE
HLLAHASERE LTMFQRLAQN AASLVALTSC GTVKGRNPDG ALISGLLRVL QNENPASQYI
SIDIDADNFS VEEGDGKDLA RCIVDRESEL HQGDFADEVE RNPMDREFSW HDGCMWISRH
VPDAGFHSQH GLDPRAIKPD LLPLGSQGAV RAAFETPGVL NSLCFTPYKE LLQPLPSGFI
DVAVAAVGLS MRDLDHWTGR VDGDHLSSEY SGIVTAVGAG VDNLKVGDLV YGLGKGQFGN
YTRVPASLAR KLGLESDMVR MASMPLAYST AIYLLDHVAR ARKGQSVLIQ SGAKDDGLAA
IHLAKAKGAD VFAMAETNEQ ATFLMNELGM PASHVISTPT LAALRHAAQS TSSGKFDIIV
STTRDKLVYS FLQVLAPLGH LIELGRADSQ TSPALSLESL PRNASYSSVD PFDILVSRPD
LGAELMQAVD NYYQKGLIQP IPKITAPDVS QMGPAIASLP SMIGKLVVSF ESPESLVRMT
PAPPTVSFDH ESCYVITGAL GGLGQSLIRW MGDRGARHMA ILSRRGIADA SGAKELVESL
GRRGIQVESF VCDLSNKDQV VSVMQQISSK RPIKGIVHAA VSYLDLSFDK LSPSRWNQGL
AAKVDGTKNL HEATLSMPLD FFVMITSALA VYAFATQGAY TAANNFQDVF ARYRRRMGLV
ASTASFSLIR DITNVGTSDL TVDLFERNKT VTLGESQFLT SFEPAFLNNT TSANNLDSDG
GDDSSEEQWF GQRDDPLSAA NLHTYLDPAA MLARRQQELA SGAAGSSSIP RWYGDGRVSR
MMRGFLDAQR QSADLQASAA AAEEAGGKAT PASVRREFEA AVRSGGAGGR AATVALVQDA
IVRAVAEMLF VDVEGIDPAK SVAELGVDSL IAAELRSWFL KALGASISML DLLDPSVSIA
TRAASITDKA LEESA
//
