ID   A0A175YP52_DAUCS        Unreviewed;       782 AA.
AC   A0A175YP52;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=DCAR_027084 {ECO:0000313|EMBL:KZM85494.1};
OS   Daucus carota subsp. sativus (Carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC   Daucus; Daucus sect. Daucus.
OX   NCBI_TaxID=79200 {ECO:0000313|EMBL:KZM85494.1, ECO:0000313|Proteomes:UP000077755};
RN   [1] {ECO:0000313|EMBL:KZM85494.1, ECO:0000313|Proteomes:UP000077755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DH1 {ECO:0000313|Proteomes:UP000077755};
RC   TISSUE=Leaf {ECO:0000313|EMBL:KZM85494.1};
RX   PubMed=27158781; DOI=10.1038/ng.3565;
RA   Iorizzo M., Ellison S., Senalik D., Zeng P., Satapoomin P., Huang J.,
RA   Bowman M., Iovene M., Sanseverino W., Cavagnaro P., Yildiz M.,
RA   Macko-Podgorni A., Moranska E., Grzebelus E., Grzebelus D., Ashrafi H.,
RA   Zheng Z., Cheng S., Spooner D., Van Deynze A., Simon P.;
RT   "A high-quality carrot genome assembly provides new insights into
RT   carotenoid accumulation and asterid genome evolution.";
RL   Nat. Genet. 48:657-666(2016).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KZM85494.1}.
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DR   EMBL; LNRQ01000008; KZM85494.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A175YP52; -.
DR   STRING; 79200.A0A175YP52; -.
DR   EnsemblPlants; KZM85494; KZM85494; DCAR_027084.
DR   Gramene; KZM85494; KZM85494; DCAR_027084.
DR   OMA; MWIVVID; -.
DR   Proteomes; UP000077755; Chromosome 8.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000077755};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..782
FT                   /note="Cullin family profile domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008044830"
FT   DOMAIN          427..657
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   782 AA;  91196 MW;  B9F0B67EDA227486 CRC64;
     MWIVVIDVIV LGVFCLSRCE GLGFGFWGLR NEVQSCESVT MNDRKTVDLD HGWEFMQRGI
     TKLKRILEGL PEPQFSSEDY MMLYTTIYNM CTQKPPHDYS QQLYDKYREA FQEYISSTVL
     PSLREKHDEF MLRELVNRWV NHKVMVRWLS RFFHYLDRYF IARRSLPGLN EVGLTCFRDL
     VYQELKGKVR DAVISLIDQE REGEQIDRAL LKNVLDIYVE IGMGQMDQYE SDFEEAMLKD
     TAEYYSRKAS NWILEDSCPD YMLKAEECLR REKDRVSHYL HFSSEPKLLE KVQNELLSVY
     ATQLLEKEHS GCHALLRDDK VDDLSRMYRL FSKIPKGLDP VSNIFKQHVT NEGTTLVKQA
     EDAASNKKAE KRDIVGQQEQ VFVRKIIELH DKYLTYVNDC FANHTLFHKA LKEAFEIFCN
     KGVAGSSNAE LLATFCDNIL KKGGTEKLSD EAIEETLEKV VKLLAYISDK DLFAEFYRKK
     LARRLLFDKS ANDEHERSIL TKLKQQCGGQ FTSKMEGMVT DLTLAKENQS SFEEYLANNS
     NVNPGIDLTV TVLTTGFWPS YKSFDLNLPA EMVKCVEVFR EFYQTKTKHR KLTWIYSLGT
     CNVLGKFEPK TIELIVTTYQ ASALLLFNSS DRLSYQEIMS QLNLSDDDVV RLLHSLSCAK
     YKILTKEPNT KTISPTDYFE FNSKFTDKMR RIKIPLPPVD EKKKVIEDVD KDRRYAIDAS
     IVRIMKSRKV LGYQQLVMEC VEQLGRMFKP DVKAIKKRIE DLITRDYLER DKDNANLFRY
     LA
//