ID A0A175YQ73_DAUCS Unreviewed; 787 AA.
AC A0A175YQ73;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=DCAR_027188 {ECO:0000313|EMBL:KZM85390.1};
OS Daucus carota subsp. sativus (Carrot).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC Daucus; Daucus sect. Daucus.
OX NCBI_TaxID=79200 {ECO:0000313|EMBL:KZM85390.1, ECO:0000313|Proteomes:UP000077755};
RN [1] {ECO:0000313|EMBL:KZM85390.1, ECO:0000313|Proteomes:UP000077755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH1 {ECO:0000313|Proteomes:UP000077755};
RC TISSUE=Leaf {ECO:0000313|EMBL:KZM85390.1};
RX PubMed=27158781; DOI=10.1038/ng.3565;
RA Iorizzo M., Ellison S., Senalik D., Zeng P., Satapoomin P., Huang J.,
RA Bowman M., Iovene M., Sanseverino W., Cavagnaro P., Yildiz M.,
RA Macko-Podgorni A., Moranska E., Grzebelus E., Grzebelus D., Ashrafi H.,
RA Zheng Z., Cheng S., Spooner D., Van Deynze A., Simon P.;
RT "A high-quality carrot genome assembly provides new insights into
RT carotenoid accumulation and asterid genome evolution.";
RL Nat. Genet. 48:657-666(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476, ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZM85390.1}.
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DR EMBL; LNRQ01000008; KZM85390.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A175YQ73; -.
DR STRING; 79200.A0A175YQ73; -.
DR EnsemblPlants; KZM85390; KZM85390; DCAR_027188.
DR Gramene; KZM85390; KZM85390; DCAR_027188.
DR OMA; FLKINMT; -.
DR Proteomes; UP000077755; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:EnsemblPlants.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:EnsemblPlants.
DR GO; GO:0009826; P:unidimensional cell growth; IEA:EnsemblPlants.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002251; Cl_channel_pln.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF136; H(+)_CL(-) EXCHANGE TRANSPORTER 6; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01120; CLCHANNELPLT.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000077755};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 67..88
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 108..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 223..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 310..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 441..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 696..753
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 768..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 86080 MW; 972A4C0A98EE76F1 CRC64;
MISNHLHNGM ESAKLMWSRL PNSEDADFEG LSPSESSGAG GGGSVESLDY EAQRGKLYVG
FYVGVKWFFA LLIGVGTGLA AVFINISVEN FAGWKYSLTF SIIQKSYIAG FIVFVLINLA
LVYSSVYIIT QFAPAAAGSG IPELKGYLNG IDTHGILLFR TLIGKIFGSI GSVGGGLALG
KEGPLVHTGA CIASLLGQGG STKYHLSSRW LQVFKSDRDR RDLVTCGCAA GVAAAFRAPV
GGVLFALEEV TSWWRSQLMW RVFFTSAIVA VVVRTAMGWC KSGKCGHFGS GGFIIWDVSD
GQEDYSFVEL LPMAVIGVIG GLLGALFNQL TLYLTHWRRN YLHKRGSRVK MIEVCLISVI
TSAISFGLPL FRKCTPCPEV DVNSGIECPR PPGMYGNYVN FYCSNDKEYN DLATIFFNTQ
DDAIRNLFSA KTIHEFSAQS LLTFLVMFYS LAVVTFGTAV PAGQFVPGIM IGSTYGRLVG
KFVVSFYKKL NIEEGTYALL GAASFLGGSM RMTVSLCVIM VEITNNLKLL PLIMLVLLIS
KAVGDAFNEG LYEEQARLRG IPLLESRPKY QMRQMTAKEA CGNQKVVYFP RVAKVADVVS
ILMSNSHNGF PVIDHTRSGE TLVIGLVLRS HLLVLLQSKA DFQHSPLPSA LRGRSLPIRH
RISEFVKPAS SKGLSIHDIH LSHDDLEMYI DLAPFVNPSP YIVPDDMSLT KVYNLFRQLG
LRHIFVVPRA SRVLGVITRK DLLIEGDEDS SAVELQSASV RSLSQRDKRL SKRNADVEPP
LLDGLLG
//
