ID A0A176KTB5_9ACTN Unreviewed; 933 AA.
AC A0A176KTB5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:OAA95568.1};
GN ORFNames=A6P39_39595 {ECO:0000313|EMBL:OAA95568.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA95568.1};
RN [1] {ECO:0000313|EMBL:OAA95568.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA95568.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA95568.1}.
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DR EMBL; LWRP01000202; OAA95568.1; -; Genomic_DNA.
DR RefSeq; WP_067057169.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176KTB5; -.
DR STRING; 710705.A6P39_39595; -.
DR OrthoDB; 118142at2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd16936; HATPase_RsbW-like; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13581; HATPase_c_2; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF07228; SpoIIE; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00091; PAS; 1.
DR SMART; SM00331; PP2C_SIG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:OAA95568.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:OAA95568.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 240..280
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 933 AA; 99845 MW; 1383362A53DA02D3 CRC64;
MEVFSGRPRS PERHPPAGRP RRRRTPLPDR HSVAGQVFLV QVAIVVLLVL AAVAAMVVQT
ARDAVQRGRR ESVVAAQSFA SAPGTAAALQ SRDPTAVLQP RAEQARKRAG VDFVVVTNTQ
GIRYTYPYPQ EIGKKFVGTI APALQGRTVV EQAGGPPLPA GRGTAVQAVV PVTDSHGKVV
GLVSAGITVR NVAGLWMPQL PIILGSGAAA LALAMTGTTL LSRRLRRQTH GLAPAELAQQ
YEHHEAVLHA VREGVLITRA DGRLLLANDE ARRLLGLPAD VRGRPVRELG LPEPITRLLT
SPGVVTDEVH RAGDRLLAVN KRPTYPDADR GGSVVTLRDT TELATVSGRA EVARERLKVL
YEAGVGIGTT LDVGRTAQEL ADVAAPQFAD LVTVDLLDAV LRGWEPTAEG WRHLRRAAIG
GEQRMVPVYP LGEVIAFSAR TPQMRTLQEG RALLEPDLRQ AHGWREQDPE RARKALESGL
CSLVSAPLRA RDVPLGVANF YRTAASPAFG PEDLVFAEEL AARAAVALDN ARRFTREHAM
AVTLQRSLLP RSQPEQDALE VAWRYLPAEA GVGGDWFDVI PLPGARVALV MGDVVGHGLH
AAATMGRLRT AVHNFSTLDL PVDEVLGNLD DLVVRMDDEE NADDAGAGHE GEGVTGATCL
YAVYDPVAGL CTMARAGHPE PVVVRPDGTV TCPGVPASAP LGLGGYPFET AELSLPEGSQ
LVLYTDGLVE DRAHGIDAGM ARLHRALTGS GGRSPEETCQ AVIDTLKPSH SSDDIALLAA
RTRMFPPSRM AEWDVPSDPA VVPSARARCR KTVREWGLEE AGFATELIVS ELVTNAIRYG
SPPVRVRLLH ARSLICEVSD GSGTSPRLRR AATTDEGGRG LFLVAQFAQR WGTRYTARGK
VIWTEQLLDE GTSAATGPTP VDFLLDQFDD PGT
//
