ID A0A176KW84_9ACTN Unreviewed; 388 AA.
AC A0A176KW84;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=A6P39_35140 {ECO:0000313|EMBL:OAA96174.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA96174.1};
RN [1] {ECO:0000313|EMBL:OAA96174.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA96174.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAA96174.1}.
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DR EMBL; LWRP01000175; OAA96174.1; -; Genomic_DNA.
DR RefSeq; WP_067054736.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176KW84; -.
DR STRING; 710705.A6P39_35140; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06109; BsCS-I_like; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF23; CITRATE SYNTHASE 2-RELATED; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 273
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 326
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 388 AA; 42014 MW; E8A37EBBD7203B1C CRC64;
MSINRTATPL IDAPRGLAGV VVTETEIGDV RGREGFYHYR QYSAVELART RGFEDVWHLL
VHGALPDARC RAAFTAETAA LRRLPEEVRA ALPAIAAASR VSGPLSGLRT ALSLLGAARG
MRPVYDIDAD RRRADTLAAC AAVPTLLTAL YRLGQGLDPV EPREDLTYAA NYLYMLTGEE
PEQRRARAVE QYLISTIDHG FNPSTFTARV IASTGADVVA CLTGAVGALS GPLHGGAPSR
ALDTLDAIGT PDRIDPWIRE RVLGGDRIMG FGHAIYRTED PRSRMLREIA QSFGGPRVDF
AVQVERRVEA ILAELKPGRE LHINVEFYAG VVMELCGLPR EMFTPTFAAA RVVGWSANIL
EQAADSKIIR PVARYVGPEP PAAVPAQP
//
