ID   A0A176L5R1_9ACTN        Unreviewed;       306 AA.
AC   A0A176L5R1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=5'-3' exonuclease {ECO:0000313|EMBL:OAA99643.1};
GN   ORFNames=A6P39_16765 {ECO:0000313|EMBL:OAA99643.1};
OS   Streptomyces sp. FXJ1.172.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=710705 {ECO:0000313|EMBL:OAA99643.1};
RN   [1] {ECO:0000313|EMBL:OAA99643.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAA99643.1};
RA   Liu M., Liu N., Shang F., Huang Y.;
RT   "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT   from red soil-derived Streptomyces sp. FXJ1.172.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAA99643.1}.
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DR   EMBL; LWRP01000087; OAA99643.1; -; Genomic_DNA.
DR   RefSeq; WP_067046076.1; NZ_CP119133.1.
DR   AlphaFoldDB; A0A176L5R1; -.
DR   STRING; 710705.A6P39_16765; -.
DR   OrthoDB; 9806424at2; -.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000313|EMBL:OAA99643.1};
KW   Hydrolase {ECO:0000313|EMBL:OAA99643.1};
KW   Nuclease {ECO:0000313|EMBL:OAA99643.1}.
FT   DOMAIN          3..275
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
SQ   SEQUENCE   306 AA;  33168 MW;  C83CD66F1E2316BE CRC64;
     MTGRLMLLDT ASLYFRAYFG VPDSVKAPDG TPVNAVRGLL DFIDRLVRDH RPEQLVACMD
     ADWRPQWRVD LIPTYKAHRV AEEHEAGPDE EEVPDTLAPQ VPVIEDVLDA IGIARVGVAG
     YEADDVIGTF TARAKGPVDI VTGDRDLYQL VDDARGIRVL YPLKGVGTLQ LTDEAVLREK
     YGVDGRGYAD LALLRGDPSD GLPGVAGIGE KTAAKLLAEF GDVDRIMAAL DDPQARLTPS
     QRKRLDEARP YVAVAPKVVR VAADVPLPDV DTALPHTPRD PAELERLAGR WGLGGSLQRL
     LTTLAG
//