ID A0A176LA74_9ACTN Unreviewed; 1032 AA.
AC A0A176LA74;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=ATP-dependent DNA helicase RecG {ECO:0000313|EMBL:OAB01244.1};
GN ORFNames=A6P39_07445 {ECO:0000313|EMBL:OAB01244.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAB01244.1};
RN [1] {ECO:0000313|EMBL:OAB01244.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAB01244.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAB01244.1}.
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DR EMBL; LWRP01000050; OAB01244.1; -; Genomic_DNA.
DR RefSeq; WP_067041206.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176LA74; -.
DR STRING; 710705.A6P39_07445; -.
DR OrthoDB; 9804325at2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF14528; LAGLIDADG_3; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OAB01244.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 438..523
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 583..756
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 779..959
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 443..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 111665 MW; 6C0F36D5BA755854 CRC64;
MDLVPALEEP LKQPLKSVLG PATAKVMAEH LGLHTVGDLL HHYPRRYEER GQLTHLADLP
MDEHVTVVAQ VADARLHTFA SAKAPRGKGQ RLEVTITDGS GRLQLVFFGN GVHKPHKELL
PGTRAMFAGK VSVFNRRLQL AHPAYELLKG DGDETVEAWA GALIPIYPAT AKLESWKIGK
AVQTVLPTAQ EALDPLPPAL REGRGLVPLP EALLKIHRPH TKADIADARA RLKWDEAFVL
QVALARRRHA DAVLPAVARR PKADGLLTAF DDRLPFTLTE GQRKVSREIF DDLATEHPMH
RLLQGEVGSG KAQPLDSLVL TPAGFRRMGD VRVGDEVVVP DGGIAVIDGV FPQGEREVWR
MVLCDGSAVE SDEEHLWIVA TSEGWRRGQD PKVMTTRDIR TDTLEADGSP KWYLPAAVPV
DLGDDAGLPA DPYRLGRRLG RLAEDGSSRH DAPPATAGDE IPAQSTGVPD AFKNTSVKNR
LALLQGLLDA EGTVGEDGLD ISLRSASRRL ADDVAWLVRS LGGRAHVLAR HGAFDVALAL
PDAYAPFRLA RKAGRMRPRP GGDTFRRAVR AVEYVGRKPV QCISVAHPSH AYVTDHFTVT
HNTMVALRAM LAVVDAGGQA AMLAPTEVLA QQHHRSITEM MGELAEGGML GGAEQATKVV
LLTGSMGAAT RRQALLDLVT GEAGIVIGTH ALIEDKVQFH DLGLVVVDEQ HRFGVEQRDA
LRGKGKQPPH LLVMTATPIP RTVAMTVFGD LETSVLDQLP AGRSPIASHV VPAADKPHFL
ARAWERIREE VAGGHQAYVV CPRIGDDVDE APDAKKAGRK SPEDEAEKRP PLAVLEVAEQ
LAKGPLQGLK VEVLHGRMHP DDKDAVMRRF AAGETDVLVA TTVIEVGVNV PNATAMVIMD
ADRFGVSQLH QLRGRVGRGS APGLCLLVTE MPEAAAARQR LNAVASTLDG FELSRIDLEQ
RREGDVLGQA QSGARTSLRV LAVIEDEEVI AEARQEATAV VTADPELERL PGLRTALDAL
LDEEREQYLE KG
//
