ID A0A176LCW5_9ACTN Unreviewed; 478 AA.
AC A0A176LCW5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Multidrug efflux pump Tap {ECO:0000256|ARBA:ARBA00040914};
GN ORFNames=A6P39_03115 {ECO:0000313|EMBL:OAB02144.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAB02144.1};
RN [1] {ECO:0000313|EMBL:OAB02144.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAB02144.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Drug:H(+)
CC antiporter-3 (DHA3) (TC 2.A.1.21) family.
CC {ECO:0000256|ARBA:ARBA00038075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAB02144.1}.
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DR EMBL; LWRP01000018; OAB02144.1; -; Genomic_DNA.
DR RefSeq; WP_067039271.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176LCW5; -.
DR STRING; 710705.A6P39_03115; -.
DR OrthoDB; 4544213at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR23513:SF6; MULTIDRUG EFFLUX PUMP TAP; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 47018 MW; 7F4FBEE2F7157E76 CRC64;
MEDIGRSRLP RRSGKASTTP GAAPPPADTG IRTAGGRDLT VLWGINFIDG LGSQASGLVF
PLLLLDLGHG RGTAGAFASA AALAGVVLSP FVALPADRGR RRTLMTGTSV SASLAMAGLA
ACCLGHPPLW VLLGLALTER LCATAYEAAA RGALSRLAGA ADLPRAVAGV QAGDQAALVL
GPALGGVLFS VSPLLPFAVD AGSYAAAAFG VRAVRTPLDG TPAGPPHGPD APGNPADVPP
ATSAMVPDSP RSSSDPPVGT VRSGALRAGV AAVVGSPVLR LVLLWSSAAS GAVALLFYNA
LFVLGTEAGS IATGGVLAAS GAAGLAGSLV AARAVRRLGA HRSLTVATWL LLPPCAALSV
AREPWSWTLC FCGLCLVLPV VTVVLGAAAV RAVPAELQSR SGAVLGSAGA LTAAGGPAGA
ALLMAWGGPG APAVACTVIL ALLAVHTQHT ANTVLRPLTP AHADQDTGRT SSRAGGAR
//
