ID A0A176TCA3_9FLAO Unreviewed; 1111 AA.
AC A0A176TCA3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=LPB303_08330 {ECO:0000313|EMBL:OAD45389.1};
OS Polaribacter atrinae.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1333662 {ECO:0000313|EMBL:OAD45389.1, ECO:0000313|Proteomes:UP000076923};
RN [1] {ECO:0000313|EMBL:OAD45389.1, ECO:0000313|Proteomes:UP000076923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KACC 17473 {ECO:0000313|EMBL:OAD45389.1,
RC ECO:0000313|Proteomes:UP000076923};
RA Shin S.-K., Yi H.;
RT "Draft genome sequence of Polaribacter atrinae KACC17473.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAD45389.1}.
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DR EMBL; LVWE01000029; OAD45389.1; -; Genomic_DNA.
DR RefSeq; WP_068449566.1; NZ_LVWE01000029.1.
DR AlphaFoldDB; A0A176TCA3; -.
DR STRING; 1333662.LPB303_08330; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000076923; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000076923}.
FT DOMAIN 569..730
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 739..905
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1111 AA; 127393 MW; 39AFA962C00909AA CRC64;
MSKQNIVNQY QKSANVSQII NQLQQDKNHF QISNLVGSSL SFVISETFKK ADKPYLLIFN
DKEEAAYYLN DLEQLLGEKN VLFYPGSYRR PYQIEETDNA NVLLRSEVLN RINSRKKPAI
IVTYPTALFE KVVTKKELEK NTLKVAVGES LSLDFVNEVL FEYKFKRVDF VTEPGDFSVR
GGIIDVFSFS NDEPYRVEFF GDEIDSIRSF DVETQLSKEK LKKISIMPNV ENKTLEENRE
SFLKYISSKT VIFAKNTDLL VGNLDKFYQK AEEAFLSLSK EIKHAKPSEL FCDGNFIKNQ
LHEFSLIEMS PKVQSKELLE IEFNTIAQPS FNKQFNLLID NLEEYHKAKF TSYIFCANDQ
QAKRFHDIFD DAEQEVHYET VVFPLYQGFV DVDNRLVCYT DHEIFERYHK FRLKNGYAKK
QAITLQDLNK LEIGDYVTHM DHGIGKFGGL QKIDVQGRKQ EAIKLVYGER DILYVSIHSL
HKISKFNGKD GKAPKIYKLG SGAWKKIKQK TKARVKHVAF NLIQLYAKRK LQKGFSFGPD
THIQHELEGS FMYEDTPDQF TATQAVKQDM EKEQPMDRLV CGDVGFGKTE VAVRAAFKAV
DNGKQVAILV PTTILAFQHY KTFTERLKDF PVRIDYLNRF RTAKQKTEAI NGVNDGSVDI
IIGTHQLTNK RLQFKDLGLL VIDEEQKFGV AVKDKLKTLK ENVDTLTLTA TPIPRTLQFS
LMAARDLSVI KTPPPNRHPI ESNVIRFSEE TVRDAIAYEI SRGGQVFFIH NRIENIKEVA
GLIQRLVPNA KVGIGHGQME GKKLEGLMLG FMNGDFDVLV STTIIESGLD VPNANTIFIN
NANNFGLSDL HQMRGRVGRS NKKAFCYFIT PPYHMMTDDA RKRIEALVLF SDLGSGINIA
MKDLEIRGAG DLLGGEQSGF INDIGFDTYQ KILQEAIEEL KENEFKELYP TNNSKPKEYV
KEVTIDTDFE ILFPDDYINS ITERLALYNK LGELKSEEEL QVFETEIIDR FGEIPTQVED
LLDSVRIKWL AKELGLEKVI LKQKRMMGYF VANQQSEFYQ TDAFTRMLKY VQQNPKSCVM
KEKESKNGLR LLITFIRIDT VKTALGVLQK V
//
