ID A0A177CAG5_9PLEO Unreviewed; 1262 AA.
AC A0A177CAG5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN ORFNames=CC84DRAFT_1219041 {ECO:0000313|EMBL:OAG03768.1};
OS Paraphaeosphaeria sporulosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Didymosphaeriaceae;
OC Paraphaeosphaeria.
OX NCBI_TaxID=1460663 {ECO:0000313|EMBL:OAG03768.1, ECO:0000313|Proteomes:UP000077069};
RN [1] {ECO:0000313|EMBL:OAG03768.1, ECO:0000313|Proteomes:UP000077069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP3s5-JAC2a {ECO:0000313|EMBL:OAG03768.1,
RC ECO:0000313|Proteomes:UP000077069};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000256|ARBA:ARBA00002558}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; KV441554; OAG03768.1; -; Genomic_DNA.
DR RefSeq; XP_018034133.1; XM_018183050.1.
DR AlphaFoldDB; A0A177CAG5; -.
DR STRING; 1460663.A0A177CAG5; -.
DR GeneID; 28766536; -.
DR InParanoid; A0A177CAG5; -.
DR OrthoDB; 1779375at2759; -.
DR Proteomes; UP000077069; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW Protease {ECO:0000313|EMBL:OAG03768.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077069};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 474..552
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT DOMAIN 1047..1128
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT REGION 76..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1262 AA; 139240 MW; B9F6A30B65CE312C CRC64;
MSDTEKNSGA GKANSGWTDK ERLVYLIGLL ENSGTKLDFK NAPRPNGRSE IACERMVGRL
KTAYKAELDA LKAGQHLDGG DAATPKKRGS KAKGTGGDDE GTPKTPKRKG KTAVEDGGSP
KKKGKKTDAT AEVKDELAMS SLAGAFRHLH LAPHLVTQRR RFTTDPMPAE HHGEHDTRSK
RKQPPTPSSE RPMKQIKPEA THARNGTYAA AESEPLARDQ SPTPSMDIDE FVPPQIAAAV
HDTAEWQRTI ETVVKSVVSI HFCQTCSFDT DPAVASEATG FVVDAERGYI LTNRHVVGAG
PFIGYCIFDN HEECDVFPVY RDPVHDFGIL RFDPKEIKYM PVTALELHPK KAQVGVEIRV
VGNDAGEKLS ILSGVISRLD RNAPEYGEGY SDFNTNYIQA AAAASGGSSG SPVVNVNGHA
VALQAGGRAD GAATDYFLPL DRPLRALELI REGKPVSRGT IQTQWILKPF DECRRLGLSP
DVEKAVRTQF PKETGMLVAE VVLKNGPASK HVEEGDVLVK VNGELLTQFV RLDAVLDDSV
GGKVSLTIQR AGEDLEVELD VTDLHAITPD RFISVAGASF HDLSYQQARL YAISLENAGV
YVCEAAGSFR FAEGFTSGWL VQEVDNQPTP NLEAFIEVMR KIPDRKRVVM VYKHLRDLHT
ANTSITTIDR HWHAKMRVAK RNDETGLWDF TTIADAIPAV PNVPRKANFI KLTSNFPAAV
DIIRSFVRVH VHMPIKLDGF PKSNKQGYGV VVDAEQGLVL VSRALLPYDL CDISLIIADS
IFVDAKVVFM HPLQNYAIIK YDTSLVNAPV KTPKFATEFI KKGDETIFFG MNQNFRPVVT
KTSVTDISTV AIPASAVTPR YRATNFDAIT VDTNQASHSH SGVLVAEDGT VQALWLSYLG
ERTSQSGKDV EYHLGLAVPM ILPVLEQIRS GKTPKLRILN VEFQTVQMSQ ARVMGVPEEW
IEKTEHEDPE RHQLFMVRKV DSGHEGGLME GDVLLTLNGK LITRAPDLDV MYDHDFLDAA
IVRKRQEVTL KVPTVATEDL ETARVVNFCG ATLHRPHQAV RQQISRIHSD VYISSRSRGS
PAYMYGLAPT NFLTHVNNVP TPDLDSFLRE AKKIADNEYF RLKVVTFDNV PWVATMKKNE
HYFPTIEYLK DSEEELGWKK IIHEADAGGA REEIAPAEVE GGGEEMPFLA GLETAALISG
LALSSGIAIP WITTVERREL RDENAALRAQ GRREISYGKY LWRKIWHGEK LSRVTGGDVE
SE
//
