ID A0A177D7N3_ALTAL Unreviewed; 544 AA.
AC A0A177D7N3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Homocysteine synthase {ECO:0000313|EMBL:RYN65486.1};
DE SubName: Full=O-acetylhomoserine ami {ECO:0000313|EMBL:OAG15190.1};
GN ORFNames=AA0117_g12140 {ECO:0000313|EMBL:RYN65486.1},
GN CC77DRAFT_1080488 {ECO:0000313|EMBL:OAG15190.1};
OS Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC Alternaria sect. Alternaria; Alternaria alternata complex.
OX NCBI_TaxID=5599 {ECO:0000313|EMBL:OAG15190.1, ECO:0000313|Proteomes:UP000077248};
RN [1] {ECO:0000313|EMBL:OAG15190.1, ECO:0000313|Proteomes:UP000077248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRC1lrK2f {ECO:0000313|EMBL:OAG15190.1,
RC ECO:0000313|Proteomes:UP000077248};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000291422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FERA 1177 {ECO:0000313|Proteomes:UP000291422};
RA Armitage A.D., Cockerton H.M., Sreenivasaprasad S., Woodhall J., Lane C.,
RA Harrison R.J., Clarkson J.P.;
RT "Genomics, evolutionary history and diagnostics of the Alternaria alternata
RT species group including apple and Asian pear pathotypes.";
RL bioRxiv 0:0-0(2019).
RN [3] {ECO:0000313|EMBL:RYN65486.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FERA 1177 {ECO:0000313|EMBL:RYN65486.1};
RA Armitage A.D., Cockerton H.M., Sreenivasaprasad S., Woodhall J., Lane C.,
RA Harrison R.J., Clarkson J.P.;
RT "Genomics, evolutionary history and diagnostics of the Alternaria alternata
RT species group including apple and Asian pear pathotypes.";
RL J. ISSAAS 0:0-0(2019).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; KV441495; OAG15190.1; -; Genomic_DNA.
DR EMBL; PDXD01000065; RYN65486.1; -; Genomic_DNA.
DR RefSeq; XP_018380611.1; XM_018529320.1.
DR STRING; 5599.A0A177D7N3; -.
DR GeneID; 29114914; -.
DR KEGG; aalt:CC77DRAFT_1080488; -.
DR VEuPathDB; FungiDB:CC77DRAFT_1080488; -.
DR OMA; IGNPRCS; -.
DR OrthoDB; 6018at2759; -.
DR Proteomes; UP000077248; Unassembled WGS sequence.
DR Proteomes; UP000291422; Unassembled WGS sequence.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|RuleBase:RU362118};
KW Reference proteome {ECO:0000313|Proteomes:UP000077248}.
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 59885 MW; 5A374BA62BE4A141 CRC64;
MAPFVEDENN VAATNGTSRP DSSTTNGTTS GTTNNQKIPD PNGITLSQLP ENHDPLQPYK
IDKFDDGLRY DTLQIHGGHR PDKETHARAV PIYNSVSFVF TDSNHAKRIC STEEGGYFYS
RISNPTVAVF EKRAAALEGG TAAIATSSGQ AAIFNTIICL AGAGDNIIAS INLYGGTYSL
FKTLLPRLGI TVKWAKREIR EEFEQYIDDK TKMIFVETIG NPRCSIPDLQ DLGDLAHENN
VPFVVDNTFG ACGTWCRPID FGANIIVHSA TKWMGGHGTT LGGVIIDCGT FDWGKAIHRF
PRLSNKDGPM SFSYWKSFGN ICFAMAMRID ILMEVGSMLA PASAQQLLIG METLSIRCER
HARNTMQVAR FLQAHPRIAW VNYPGLEGNI YHENAKRYLK NGFGGVLAFG PKGGEVASKM
LMNYVKVVSH QTNVGDAKTL ATHPWNSTHV IMSEKDRREA GITPAFIRFS VGIEDVQDII
DDLDQALAKL PEDLLNAFDE KLIQKLETHT KDEVLIGDLA DYNDTDVLVS KTNHPPGRQQ
AVEN
//
