ID A0A177DWN4_ALTAL Unreviewed; 554 AA.
AC A0A177DWN4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=AA0117_g3686 {ECO:0000313|EMBL:RYN79668.1}, CC77DRAFT_1059110
GN {ECO:0000313|EMBL:OAG23412.1};
OS Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC Alternaria sect. Alternaria; Alternaria alternata complex.
OX NCBI_TaxID=5599 {ECO:0000313|EMBL:OAG23412.1, ECO:0000313|Proteomes:UP000077248};
RN [1] {ECO:0000313|EMBL:OAG23412.1, ECO:0000313|Proteomes:UP000077248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRC1lrK2f {ECO:0000313|EMBL:OAG23412.1,
RC ECO:0000313|Proteomes:UP000077248};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000291422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FERA 1177 {ECO:0000313|Proteomes:UP000291422};
RA Armitage A.D., Cockerton H.M., Sreenivasaprasad S., Woodhall J., Lane C.,
RA Harrison R.J., Clarkson J.P.;
RT "Genomics, evolutionary history and diagnostics of the Alternaria alternata
RT species group including apple and Asian pear pathotypes.";
RL bioRxiv 0:0-0(2019).
RN [3] {ECO:0000313|EMBL:RYN79668.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FERA 1177 {ECO:0000313|EMBL:RYN79668.1};
RA Armitage A.D., Cockerton H.M., Sreenivasaprasad S., Woodhall J., Lane C.,
RA Harrison R.J., Clarkson J.P.;
RT "Genomics, evolutionary history and diagnostics of the Alternaria alternata
RT species group including apple and Asian pear pathotypes.";
RL J. ISSAAS 0:0-0(2019).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; KV441473; OAG23412.1; -; Genomic_DNA.
DR EMBL; PDXD01000005; RYN79668.1; -; Genomic_DNA.
DR RefSeq; XP_018388833.1; XM_018528197.1.
DR STRING; 5599.A0A177DWN4; -.
DR GeneID; 29113791; -.
DR KEGG; aalt:CC77DRAFT_1059110; -.
DR VEuPathDB; FungiDB:CC77DRAFT_1059110; -.
DR OMA; EMIQMLY; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000077248; Unassembled WGS sequence.
DR Proteomes; UP000291422; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000077248};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 123..165
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 165..207
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 334..366
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 60752 MW; BA0206CFEDA4DB7B CRC64;
MADKYIPEHR RTTFKAKSAF KPDELRRRRE EQQVEIRRAK REENLAKRRG IAGRDQPGAS
LGAAPDSDDE GGNIESQLNE ELPQMVKGVF SEQIDEQIQA TTKFRKLLSK ERNPPIERVI
ETGVVSRFVE FLRSPHTLVQ FEAAWALTNI ASGSAQQTQV VIEAGAVPIF VELLSSHEPD
VREQAVWALG NIAGDSPACR DFVLQAGALR PLLALLGDSR KLSMLRNATW TLSNFCRGKT
PQPDWQTIQP ALPVLAKLVY SLDDEVLIDA CWAISYLSDG SNDKIQAVIE AGIPRRLVEL
LMHASTSVQT PALRSVGNIV TGDDVQTQVI INCGSLPALL SLLSSTKDGI RKEACWTISN
ITAGNSTQIQ AVIDANIIPP LIHLLQNGDF KTRKEACWAI SNATSGGLQK PAQIRYLVQS
GCIKPLCDLL ACPDNKIIQV ALDGLENILK VGEMDKEASE GGAGGEPINR YALFIEEVGG
MEKIHECQNN ANEEIYMKAY NIIEKYFSDE EGEAENMGEA GPQVNQEGHF GFGAAGQQQQ
QNFNFANGGD SMDM
//
