ID A0A177E3P9_ALTAL Unreviewed; 987 AA.
AC A0A177E3P9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=AA0117_g11890 {ECO:0000313|EMBL:RYN66176.1},
GN CC77DRAFT_1015840 {ECO:0000313|EMBL:OAG26565.1};
OS Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Alternaria;
OC Alternaria sect. Alternaria; Alternaria alternata complex.
OX NCBI_TaxID=5599 {ECO:0000313|EMBL:OAG26565.1, ECO:0000313|Proteomes:UP000077248};
RN [1] {ECO:0000313|EMBL:OAG26565.1, ECO:0000313|Proteomes:UP000077248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRC1lrK2f {ECO:0000313|EMBL:OAG26565.1,
RC ECO:0000313|Proteomes:UP000077248};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000291422}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FERA 1177 {ECO:0000313|Proteomes:UP000291422};
RA Armitage A.D., Cockerton H.M., Sreenivasaprasad S., Woodhall J., Lane C.,
RA Harrison R.J., Clarkson J.P.;
RT "Genomics, evolutionary history and diagnostics of the Alternaria alternata
RT species group including apple and Asian pear pathotypes.";
RL bioRxiv 0:0-0(2019).
RN [3] {ECO:0000313|EMBL:RYN66176.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FERA 1177 {ECO:0000313|EMBL:RYN66176.1};
RA Armitage A.D., Cockerton H.M., Sreenivasaprasad S., Woodhall J., Lane C.,
RA Harrison R.J., Clarkson J.P.;
RT "Genomics, evolutionary history and diagnostics of the Alternaria alternata
RT species group including apple and Asian pear pathotypes.";
RL J. ISSAAS 0:0-0(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR EMBL; KV441469; OAG26565.1; -; Genomic_DNA.
DR EMBL; PDXD01000059; RYN66176.1; -; Genomic_DNA.
DR RefSeq; XP_018391986.1; XM_018524102.1.
DR STRING; 5599.A0A177E3P9; -.
DR GeneID; 29109696; -.
DR KEGG; aalt:CC77DRAFT_1015840; -.
DR VEuPathDB; FungiDB:CC77DRAFT_1015840; -.
DR OMA; TQDYVDV; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000077248; Unassembled WGS sequence.
DR Proteomes; UP000291422; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 6.10.140.1260; -; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR021601; Phosphatidylino_kinase_fungi.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR Pfam; PF11522; Pik1; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OAG26565.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077248};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..120
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 693..972
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 181..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 108611 MW; 5656994ECD4F2580 CRC64;
MSWNLLERFI ESEHFNQDPS LAVAYLARYA DHVGIHYVLC SKLRQFAYEE LEFFLPQLCH
LLISIDNESM ALEEFIIDLC EESVNGALLT FWLFQTYLHD LASAPNSIAF KTCRRIYNRV
QRIVFGSAEP QRREKIKENV LPVTVLSSLV LASIAAPFLP AHAGPLAIAQ ARKPRPVEDI
ISDNVQTAKV GRSKTVTGGS SRSKEKRVAA QHSDPEDGRS IKASSSRPRD PKELRKAAAR
PPAAQRAPSM QHRPSLLSIA SEARLSSSSL PDFRDGKSSP LPTPPATAGL GPGPLQHGLR
KSGLPPRPLT PTALTRTQKI RLLRSNYFRN ETQFLSALED ISNRLVVVPK PARLSALRAE
LALIDQDLPA EVDIPLLSPP TLKDGIPSQS QHHRIVRINP AESTSLNSAE RVPYLLMVEV
LEEDFDFDPD TEQNQQLLEK LMLEKGTSRR RLFDITNAEY LAFDRTPPNG SDSVFEPATG
DLGSTSLIKD MDENDIASGM ARVTLPGATA NGKATAPRSS SGANTLSSVA TLSTPRTSDS
QISRSNSPGP IRRMTIPANL NSRNQAVDQP DFSALATHMR TAAQMLAQLE ASGAKRPKGE
VAAIKAKIIA SMQTLEEQNF LNEDQGPTFD TIMAESDPTA ITGEPEELED GLPVATNSGA
GAARMENDLK TGGMRRKGDR DDPSAATFGE EWSAKRERIR RSSPYGHMKN WDLISVIVKT
GADLRQEAFA CQLIDVCTKI WEEANVPVWT KRMRILVTGE SCGLIETITN GVSLHSLKRS
LTLASIAAGT NPRKRIATLK DHWLKTFGEP DSEAYIAGVG CFARSLAAYS MICYVLQLKD
RHNGNLLIDN MGHIIHIDFG FMLSNSPGSM GFEAAPFKLT QDYVDVLGGV TGSAFEEFKT
LCKKAFQALR KDAERLIMLV DLMSKNSSMD CFKAGAQTVT NSLRARLMLH LSREEAEGFV
EELVAKSVGS YYTRLYDTFQ YRTQGIY
//
