ID A0A177EBY4_9MICR Unreviewed; 459 AA.
AC A0A177EBY4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=XPG N-terminal domain-containing protein {ECO:0000259|SMART:SM00485};
GN ORFNames=NEDG_00580 {ECO:0000313|EMBL:OAG29447.1};
OS Nematocida displodere.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX NCBI_TaxID=1805483 {ECO:0000313|EMBL:OAG29447.1, ECO:0000313|Proteomes:UP000185944};
RN [1] {ECO:0000313|EMBL:OAG29447.1, ECO:0000313|Proteomes:UP000185944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JUm2807 {ECO:0000313|EMBL:OAG29447.1,
RC ECO:0000313|Proteomes:UP000185944};
RA Luallen R.J., Reinke A.W., Tong L., Botts M.R., Felix M.-A., Troemel E.R.;
RT "Discovery of a natural microsporidian pathogen with a broad tissue tropism
RT in Caenorhabditis elegans.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAG29447.1}.
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DR EMBL; LTDL01000040; OAG29447.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177EBY4; -.
DR STRING; 1805483.A0A177EBY4; -.
DR EnsemblFungi; OAG29447; OAG29447; NEDG_00580.
DR VEuPathDB; MicrosporidiaDB:NEDG_00580; -.
DR OrthoDB; 5479162at2759; -.
DR Proteomes; UP000185944; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF54; FI23547P1; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000185944}.
FT DOMAIN 1..89
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT REGION 184..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 52214 MW; 49C754EBE7D11100 CRC64;
MGIRGLWSML KGEEVDYRAL KEKRLCVDGN IVLFACIHST DVRFITEYTL TRVGKLLSLG
IDPILVFDGK KPFFKRRLGA RPTQTQTSYT PTQPEPEAPS IYAEMETTRF SSLQIDKIVS
RHNYLKKIKE KRIHGNSSLA YTLTHLKPPT KTQTIPEPSN PYQETDDLIY QLKELIFEEI
DKTNPQNTLH PDTPAAPTAA PKPEKLEKPE TSDNLEKTEK THTPNEPSEY QRQMETYTLP
KEDMYLNKES VPKEELEFSY KVITDALDIL NVKYALAPAE SDAVYKSIES ALGTNGVVTD
DSDIFLFSTQ PIYRHFFTKT HAPKVYASSS TPLPYSWLEL TILAWLLGSD YSPGIKGVGP
SKASAFIQRY REHSSSLLLD LHALSSAIAA LAPQIQPNDI SVLKRVIRIY SETEFKVKIE
NLPFKAIDKP KLSVFIKKRT NWRNTDLVLF MEMIEKTNC
//
