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Database: UniProt
Entry: A0A177EGY3_9MICR
LinkDB: A0A177EGY3_9MICR
Original site: A0A177EGY3_9MICR 
ID   A0A177EGY3_9MICR        Unreviewed;       309 AA.
AC   A0A177EGY3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Cytoplasmic tRNA 2-thiolation protein 1 {ECO:0000313|EMBL:OAG30966.1};
GN   ORFNames=NEDG_02195 {ECO:0000313|EMBL:OAG30966.1};
OS   Nematocida displodere.
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX   NCBI_TaxID=1805483 {ECO:0000313|EMBL:OAG30966.1, ECO:0000313|Proteomes:UP000185944};
RN   [1] {ECO:0000313|EMBL:OAG30966.1, ECO:0000313|Proteomes:UP000185944}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JUm2807 {ECO:0000313|EMBL:OAG30966.1,
RC   ECO:0000313|Proteomes:UP000185944};
RA   Luallen R.J., Reinke A.W., Tong L., Botts M.R., Felix M.-A., Troemel E.R.;
RT   "Discovery of a natural microsporidian pathogen with a broad tissue tropism
RT   in Caenorhabditis elegans.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAG30966.1}.
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DR   EMBL; LTDL01000023; OAG30966.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A177EGY3; -.
DR   STRING; 1805483.A0A177EGY3; -.
DR   EnsemblFungi; OAG30966; OAG30966; NEDG_02195.
DR   VEuPathDB; MicrosporidiaDB:NEDG_02195; -.
DR   OrthoDB; 5483984at2759; -.
DR   Proteomes; UP000185944; Unassembled WGS sequence.
DR   GO; GO:0002144; C:cytosolic tRNA wobble base thiouridylase complex; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0000049; F:tRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0106054; F:tRNA-uracil-34 sulfurtransferase activity; IEA:EnsemblFungi.
DR   GO; GO:0032447; P:protein urmylation; IEA:EnsemblFungi.
DR   GO; GO:0002143; P:tRNA wobble position uridine thiolation; IEA:EnsemblFungi.
DR   CDD; cd01993; Alpha_ANH_like_II; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR011063; TilS/TtcA_N.
DR   InterPro; IPR035107; tRNA_thiolation_TtcA_Ctu1.
DR   InterPro; IPR020554; UPF0021_CS.
DR   PANTHER; PTHR11807; ATPASES OF THE PP SUPERFAMILY-RELATED; 1.
DR   PANTHER; PTHR11807:SF12; CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1; 1.
DR   Pfam; PF01171; ATP_bind_3; 1.
DR   PIRSF; PIRSF004976; ATPase_YdaO; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   PROSITE; PS01263; UPF0021; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR004976-51};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR004976-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185944};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          51..232
FT                   /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01171"
FT   BINDING         54..56
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT   BINDING         60
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT   BINDING         86
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT   BINDING         164
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT   BINDING         169
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
SQ   SEQUENCE   309 AA;  34388 MW;  96E554944F6ADC41 CRC64;
     MACGMCNAAT AVTIRPSTKE KLCKPCFLHS IEEEAHRTIR ETRMFEGITT LIVGVSGGKD
     STVMAHILNL LNQKYRYGLS IKLLCIDEGI SGYRDKSIEV VRQNEKDLLL PLTILSYQET
     FGHTMDSVVS QIGRKSNCTY CGVFRRGSLE DGAKMLKGEM IATGHNADDI AETVIMNYLR
     GDISRLTRCT HALSEKSSPE VIPRCKPLMR VYEKEIVMYA FYQKLPYFST ECKYSPGAFR
     GVARTYIKSL EKLNPRFILQ IISSGDKVQK QASSTPTTKP CTICARHCSG SGGICKACLL
     LKTLNQVPN
//
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