ID A0A177EGY3_9MICR Unreviewed; 309 AA.
AC A0A177EGY3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Cytoplasmic tRNA 2-thiolation protein 1 {ECO:0000313|EMBL:OAG30966.1};
GN ORFNames=NEDG_02195 {ECO:0000313|EMBL:OAG30966.1};
OS Nematocida displodere.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX NCBI_TaxID=1805483 {ECO:0000313|EMBL:OAG30966.1, ECO:0000313|Proteomes:UP000185944};
RN [1] {ECO:0000313|EMBL:OAG30966.1, ECO:0000313|Proteomes:UP000185944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JUm2807 {ECO:0000313|EMBL:OAG30966.1,
RC ECO:0000313|Proteomes:UP000185944};
RA Luallen R.J., Reinke A.W., Tong L., Botts M.R., Felix M.-A., Troemel E.R.;
RT "Discovery of a natural microsporidian pathogen with a broad tissue tropism
RT in Caenorhabditis elegans.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAG30966.1}.
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DR EMBL; LTDL01000023; OAG30966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177EGY3; -.
DR STRING; 1805483.A0A177EGY3; -.
DR EnsemblFungi; OAG30966; OAG30966; NEDG_02195.
DR VEuPathDB; MicrosporidiaDB:NEDG_02195; -.
DR OrthoDB; 5483984at2759; -.
DR Proteomes; UP000185944; Unassembled WGS sequence.
DR GO; GO:0002144; C:cytosolic tRNA wobble base thiouridylase complex; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0000049; F:tRNA binding; IEA:EnsemblFungi.
DR GO; GO:0106054; F:tRNA-uracil-34 sulfurtransferase activity; IEA:EnsemblFungi.
DR GO; GO:0032447; P:protein urmylation; IEA:EnsemblFungi.
DR GO; GO:0002143; P:tRNA wobble position uridine thiolation; IEA:EnsemblFungi.
DR CDD; cd01993; Alpha_ANH_like_II; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR011063; TilS/TtcA_N.
DR InterPro; IPR035107; tRNA_thiolation_TtcA_Ctu1.
DR InterPro; IPR020554; UPF0021_CS.
DR PANTHER; PTHR11807; ATPASES OF THE PP SUPERFAMILY-RELATED; 1.
DR PANTHER; PTHR11807:SF12; CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1; 1.
DR Pfam; PF01171; ATP_bind_3; 1.
DR PIRSF; PIRSF004976; ATPase_YdaO; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR PROSITE; PS01263; UPF0021; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR004976-51};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR004976-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000185944};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 51..232
FT /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01171"
FT BINDING 54..56
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 86
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 164
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 169
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
SQ SEQUENCE 309 AA; 34388 MW; 96E554944F6ADC41 CRC64;
MACGMCNAAT AVTIRPSTKE KLCKPCFLHS IEEEAHRTIR ETRMFEGITT LIVGVSGGKD
STVMAHILNL LNQKYRYGLS IKLLCIDEGI SGYRDKSIEV VRQNEKDLLL PLTILSYQET
FGHTMDSVVS QIGRKSNCTY CGVFRRGSLE DGAKMLKGEM IATGHNADDI AETVIMNYLR
GDISRLTRCT HALSEKSSPE VIPRCKPLMR VYEKEIVMYA FYQKLPYFST ECKYSPGAFR
GVARTYIKSL EKLNPRFILQ IISSGDKVQK QASSTPTTKP CTICARHCSG SGGICKACLL
LKTLNQVPN
//