ID   A0A177EIG4_9MICR        Unreviewed;       551 AA.
AC   A0A177EIG4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Translation initiation factor 2A {ECO:0000313|EMBL:OAG31727.1};
GN   ORFNames=NEDG_00202 {ECO:0000313|EMBL:OAG31727.1};
OS   Nematocida displodere.
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX   NCBI_TaxID=1805483 {ECO:0000313|EMBL:OAG31727.1, ECO:0000313|Proteomes:UP000185944};
RN   [1] {ECO:0000313|EMBL:OAG31727.1, ECO:0000313|Proteomes:UP000185944}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JUm2807 {ECO:0000313|EMBL:OAG31727.1,
RC   ECO:0000313|Proteomes:UP000185944};
RA   Luallen R.J., Reinke A.W., Tong L., Botts M.R., Felix M.-A., Troemel E.R.;
RT   "Discovery of a natural microsporidian pathogen with a broad tissue tropism
RT   in Caenorhabditis elegans.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAG31727.1}.
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DR   EMBL; LTDL01000014; OAG31727.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A177EIG4; -.
DR   STRING; 1805483.A0A177EIG4; -.
DR   EnsemblFungi; OAG31727; OAG31727; NEDG_00202.
DR   VEuPathDB; MicrosporidiaDB:NEDG_00202; -.
DR   OrthoDB; 1343922at2759; -.
DR   Proteomes; UP000185944; Unassembled WGS sequence.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011387; TIF2A.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR   Pfam; PF08662; eIF2A; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000313|EMBL:OAG31727.1};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185944}.
FT   DOMAIN          282..443
FT                   /note="Translation initiation factor beta propellor-like"
FT                   /evidence="ECO:0000259|Pfam:PF08662"
FT   REGION          115..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  61704 MW;  97421B105A3DAB46 CRC64;
     MERPTSKIVC VTKNGVLLDT LDPESVEVPC NHCKTHNEIV VYADNHEVTV YNTETEEKNI
     FPIPDTKRME IAPNGTTIAI FTKDQKLNII SNTSIIHTAE KVSSFELSSE YAVYTQEAEE
     EQAPAPTPAP APTQAQPSEA SPEPEMKAKV DTVPEPTTTN PSTNPNTNPN IKKKPVPKVK
     IQKKEGVQNA PIRAIRPMKM KAFSILGGKE VDLGLSAPFT YTVVNKRLIT TRIFGEVGGD
     IEVFNLESTQ RIKKVGVHNL MSTSFFRDAK YSRDSVLCLC TVSGHTNTYY DAKILYQLHL
     TALTFSIVPV ENPISDVVFL KKDTFAVCFG NSPSKITVFN GNLEKVKELK RGVRNKMFFN
     RQENIACLAG MNNLPGTIEI VEHPSNIFIS SNEMVGCSII DWSPCGRFYL AAVTNRMAID
     NKVAVFDYYS RKIGERHFKE LIDCKFLGAD EPFKNLQSPP EKVKVEKKVA YVPPSLRTAV
     SEETSEWMPA HVIKHKERTK EKKSATLQKE LEEIMAIEER MNKGEVVPGG FLKLQKKEGL
     LKKIEKHKTP K
//