ID   A0A177EMK3_9MICR        Unreviewed;      1278 AA.
AC   A0A177EMK3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:OAG32886.1};
GN   ORFNames=NEIG_01765 {ECO:0000313|EMBL:OAG32886.1};
OS   Nematocida sp. ERTm5.
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX   NCBI_TaxID=1805481 {ECO:0000313|EMBL:OAG32886.1, ECO:0000313|Proteomes:UP000077089};
RN   [1] {ECO:0000313|EMBL:OAG32886.1, ECO:0000313|Proteomes:UP000077089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ERTm5 {ECO:0000313|EMBL:OAG32886.1,
RC   ECO:0000313|Proteomes:UP000077089};
RA   Reinke A.W., Balla K.M., Bennett E.J., Troemel E.R.;
RT   "Identification of microsporidia host-exposed proteins reveals a repertoire
RT   of large paralogous families and rapidly evolving proteins.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009439}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAG32886.1}.
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DR   EMBL; LTDK01000102; OAG32886.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A177EMK3; -.
DR   VEuPathDB; MicrosporidiaDB:NEIG_01765; -.
DR   OrthoDB; 5477220at2759; -.
DR   Proteomes; UP000077089; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038729; Rad50/SbcC_AAA.
DR   PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR   PANTHER; PTHR18867; RAD50; 1.
DR   Pfam; PF13476; AAA_23; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          6..231
FT                   /note="Rad50/SbcC-type AAA"
FT                   /evidence="ECO:0000259|Pfam:PF13476"
FT   COILED          246..273
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          305..349
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          522..562
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          721..764
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          793..919
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          966..997
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1278 AA;  147655 MW;  16A1909209F56267 CRC64;
     MSVIGKLKIK GIRSFTEEYP AAIEMQTPLT LIVGHNGTGK TTIVEALKYA TTGALPPNSK
     NGAFVHDPRV SQERETKAQI MMKFKSCEGK EYIVVRGMSQ TIGKTKRETK TVESVLWQVT
     ESGKRMICNK LSEVDCEVPI LLGSTPSVLE NVIFVHQEES TWPLGDPSVV KKKMDGIFSS
     MKFIKAIDAL TALRKEKTGE LKVLECKYEN LQQKTQHKHI IEQRIARITE RLLVVRKLSQ
     VSNERIRKFQ IDLKESQKKY ENALSEVREK EKAESELAGL STKELLSGSV VELQSILPNT
     CVEDAEELRH EASILEIEMN EIVEKIRKFE DLKVTIEESR VEIENLNGEK KKNLGLILEK
     VQNNREYLDK ACTVISDIII EIKSTDKDLS TDRTISLITE QIENLHKETK EFNINHVLLD
     TPIEAEALVD HEVCQMESVR VWIEKLEEIL DRRIQEKDIT VRTVTEEIGI LKEKQRSIII
     RSNEIRSILD VDVNEQDTSF ISEIQESENI INSNYTKTEY NKNKVFMEIE ELQQKLEICM
     KETEKRKEKE FLIEEIKRKE KELEFLPYPS EIKLSSGLPG IIECEDALIK KITVLDTKIK
     EIQTNQQKYI HNKMVSESKH MANKLLQQAK VEQSKILIDR ISGELISNGS IITRSEVLQK
     IKEGCSINLH TEFQDVLYEL YEEWGSISAS EKIYEEFLSR AEDGCPFCKS FISTGISKGH
     VQKIKNILEC IKNKKEELKE ELTIEKENTK FKQEQAKIRI LLNNLSSLFI LENIKAEDEV
     EDTHTVEEWI ILLDTLNKQL RSIKSIKNKY EEIEILKSRE NKINLISDSY GTISEKYKEK
     LEELQRIEKL EQKEQEKYIE FENRKNELRT RIKEIENRIE QRSKYKKESV SLEKEYSLLE
     SEKSKITILL QEKTELTRKI TENERIYYKT KELLKDIKIP NNNLMIINSI KERFCEIFTK
     IEILSKKKYT ENHKNTENSL KQELIEVEEK RNIINNRITA VMAIHTQKQL IKDSIRAAIL
     SEKVKECIST QDTLNHIQEE IEKLEECIMK EQKIISECVG EEYNLEKQKE EDESDVKIHC
     TAESDELSAY IMIKVLKESI SDLEKYIKSV QAAIVRYHSE KLAEVNAIIK EIWGLAYKGT
     DIDEIKIVSH LDKTYSLVMV KNGIEIDMRG RVSAGQKVLA SIVIRLALAE AFSLNCGFLS
     LDEPTTNLDS ANISGLAKAL SSIIQARKAE GGFQLLVITH DEDFVRELLA TECTEYFYRL
     ERDIVGVPKI VQVSIYDL
//