ID A0A177HKI9_9ACTN Unreviewed; 360 AA.
AC A0A177HKI9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN {ECO:0000313|EMBL:OAH10907.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:OAH10907.1};
GN Name=tcmN_1 {ECO:0000313|EMBL:OAH10907.1};
GN ORFNames=STSP_57490 {ECO:0000313|EMBL:OAH10907.1};
OS Streptomyces jeddahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1716141 {ECO:0000313|EMBL:OAH10907.1, ECO:0000313|Proteomes:UP000077381};
RN [1] {ECO:0000313|EMBL:OAH10907.1, ECO:0000313|Proteomes:UP000077381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G25(2015) {ECO:0000313|Proteomes:UP000077381};
RA Poehlein A., Roettig A., Hiessl S., Hauschild P., Schauer J., Madkour M.H.,
RA Al-Ansari A.M., Almakishah N.H., Steinbuechel A., Daniel R.;
RT "Genome sequence of Streptomyces sp. G25.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAH10907.1}.
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DR EMBL; LOHS01000117; OAH10907.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177HKI9; -.
DR STRING; 1716141.STSP_57490; -.
DR PATRIC; fig|1716141.3.peg.6043; -.
DR OrthoDB; 4145676at2; -.
DR Proteomes; UP000077381; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:OAH10907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077381};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:OAH10907.1}.
FT DOMAIN 33..109
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 133..341
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 269
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 360 AA; 38864 MW; 41BC627D3A53551F CRC64;
MPLPPARVVR AVEGLRTGLQ RLARKLAPAP FSLLEMVQGA MLSQAVYAAA ELRVAEALRD
GPLPADRLAE RVGAHPETLQ RLMRLLASNG IFAERKGGGF ELSPMGAALL EDAPMSMRGI
AVLMGHPIHW EDWSHFVDAV RSGEPSLPKL RGMTAFEFLE AKPEYGEVFM KGMGAMSTTE
TEPILAAYDF SGFGTVVDFC AGRGELLAGI LKKSPGVRGI LSDPRVGENG AADYLAEQGV
ADRCEVVAAD LFGPVPEGGD AYVLKHIVHD WPEEQALEIL RNVRAAMRPD GRLLLMEMVV
PDKPNAAHAS KLVDLWLMLL VGGKERTAVQ YGELLAKAGF RLERVVQTPA AISVVEASLR
//
