ID A0A177HY42_9ACTN Unreviewed; 306 AA.
AC A0A177HY42;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000313|EMBL:OAH15630.1};
DE EC=2.3.1.12 {ECO:0000313|EMBL:OAH15630.1};
GN Name=dlaT {ECO:0000313|EMBL:OAH15630.1};
GN ORFNames=STSP_09520 {ECO:0000313|EMBL:OAH15630.1};
OS Streptomyces jeddahensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1716141 {ECO:0000313|EMBL:OAH15630.1, ECO:0000313|Proteomes:UP000077381};
RN [1] {ECO:0000313|EMBL:OAH15630.1, ECO:0000313|Proteomes:UP000077381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G25(2015) {ECO:0000313|Proteomes:UP000077381};
RA Poehlein A., Roettig A., Hiessl S., Hauschild P., Schauer J., Madkour M.H.,
RA Al-Ansari A.M., Almakishah N.H., Steinbuechel A., Daniel R.;
RT "Genome sequence of Streptomyces sp. G25.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAH15630.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LOHS01000037; OAH15630.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177HY42; -.
DR STRING; 1716141.STSP_09520; -.
DR PATRIC; fig|1716141.3.peg.1005; -.
DR Proteomes; UP000077381; Unassembled WGS sequence.
DR GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR014276; 2-oxoglutarate_DH_E2.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR NCBIfam; TIGR02927; SucB_Actino; 1.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:OAH15630.1};
KW Pyruvate {ECO:0000313|EMBL:OAH15630.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077381};
KW Transferase {ECO:0000313|EMBL:OAH15630.1}.
FT DOMAIN 1..37
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 306 AA; 31786 MW; 6FE943D7D2F5C6D9 CRC64;
MTPLVRKLAA EHGVDLSTVK GTGVGGRIRK QDVIAAAEAA KAAAAAPAPA AAAPAAAKKA
PALEVSPLRG QTVKMTRMRK VIGDNMMKAL HSQAQLTSVV EVDVTKLMRL RAAAKDAFAA
REGVKLSPMP FYVKAAAQAL KAHPVINARI NEDEGTITYF DSENIGIAVD SEKGLMTPVI
KGAGDLNIAG IAKKTAELAG AVRANKITPD DLAGATFTIS NTGSRGALFD TVIVPPNQVA
ILGIGATVKR PAVIETAEGT VIGVRDMTYL SLSYDHRLVD GADAARYLTA VKAILEAGEF
EVELGL
//
