ID   A0A177LCF0_9BACI        Unreviewed;       783 AA.
AC   A0A177LCF0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OAH63224.1};
GN   ORFNames=AWH49_06635 {ECO:0000313|EMBL:OAH63224.1};
OS   Domibacillus aminovorans.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Domibacillus.
OX   NCBI_TaxID=29332 {ECO:0000313|EMBL:OAH63224.1, ECO:0000313|Proteomes:UP000076935};
RN   [1] {ECO:0000313|EMBL:OAH63224.1, ECO:0000313|Proteomes:UP000076935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1314 {ECO:0000313|EMBL:OAH63224.1,
RC   ECO:0000313|Proteomes:UP000076935};
RA   Verma A., Pal Y., Krishnamurthi S.;
RT   "Investigation of taxonomic status of Bacillus aminovorans.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAH63224.1}.
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DR   EMBL; LQWY01000002; OAH63224.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A177LCF0; -.
DR   STRING; 29332.AWH48_18560; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000076935; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}.
FT   DOMAIN          17..201
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          204..302
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   783 AA;  86021 MW;  A4D99847BEDBCECF CRC64;
     MNIHSKEDVN VVQHIQKAAV IGSGVMGSGI AAHLANVGIP SILLDVVPEN AENRNVLSES
     AIQKLFKQKP APLVSKQNAA LITAGNLEDD LKQLAEADWI IEVVLENLDV KKTVFEAVDS
     YRKPGSIISS NTSGISVEAM KEGRSDDFKK HFLGTHFFNP PRYLKLLELI PTSHTLPEVV
     DYMKMFGEDV LGKGVVLAKD TPNFIANRIG TYGLLNTMHI MNEMKLSPGE VDSITGPLIG
     RPKSATFRTL DVVGLDTFIH VAKNVYDQVD GEEKAVFDVP DVLLQMRDNG WIGAKAGQGF
     FKKDGQTILE LDPNSMDYIE RKKMKADSIK VAKQQKGSAK WKTLAYANDE AGQFIWKMLA
     PMLLYSAGLT GKIADNIVSI DRAMKWGFGW NEGPFEIWDH LGVREALQKM ESEGRVIPGW
     VKDMPGHFYQ DGHYYDPATK SYKPIDQQAK VIDLKQLKKE GKVIKQNSGA SLIDIGDGVA
     LLEFTSPNNA IGMDIIHMIN DAVEEVEKKY KGLVIGNQGK NFCVGANLAM ILMAAGDEDI
     WEIDMVVKGF QQAMMKIKYS TKPVVAAPFA MVLGGGTEVC LPAAHIQASM ETYMGLVETG
     VGLIPGGGGN KELYIRHLEQ MPTGVTVDLQ AVANNVFETI AMAKVSTSAL EARENNYLYR
     ADGISINSDH LLYDAKQTAI CLYEKGYTAP IRKKVPVTGE TGYAMLLLGA QSMHASGFIS
     DHDLTIAKKL AWVIAGGNVP FGSEVDEQYL LDLEREAFLQ LVTMPKTQQR MQHMLVKGKP
     LRN
//