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Database: UniProt
Entry: A0A177NZA1_9RHIZ
LinkDB: A0A177NZA1_9RHIZ
Original site: A0A177NZA1_9RHIZ 
ID   A0A177NZA1_9RHIZ        Unreviewed;       495 AA.
AC   A0A177NZA1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   16-JAN-2019, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=A1351_19815 {ECO:0000313|EMBL:OAI23358.1};
OS   Methylosinus sp. R-45379.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylocystaceae; Methylosinus.
OX   NCBI_TaxID=980563 {ECO:0000313|EMBL:OAI23358.1, ECO:0000313|Proteomes:UP000078138};
RN   [1] {ECO:0000313|EMBL:OAI23358.1, ECO:0000313|Proteomes:UP000078138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R-45379 {ECO:0000313|EMBL:OAI23358.1,
RC   ECO:0000313|Proteomes:UP000078138};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAI23358.1}.
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DR   EMBL; LUUM01000295; OAI23358.1; -; Genomic_DNA.
DR   RefSeq; WP_051465390.1; NZ_LUUM01000295.1.
DR   EnsemblBacteria; OAI23358; OAI23358; A1351_19815.
DR   Proteomes; UP000078138; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000078138};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078138}.
FT   DOMAIN      189    322       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      403    472       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     197    204       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   495 AA;  54752 MW;  88713ABA56A77842 CRC64;
     MSDNSDDQSN SSELSAEGRQ KWERVRGRLR AELGEAVYSS WFARLELEGM KDGAALLTVP
     TKFLKSWIQS HYADRIRTRL CAEFTSLEQI VIDVRSPTRR ARPRDADAVS GAVVEKAQPA
     PAAIVVERSE AQHVKAPMRP AARGDGESFG GSPLDRRLSF STFLVGPSNQ LAYAAACRVA
     DARPGEHPLF NPLYTHAAVG LGKTHLLQAV ARSANDNKRR VLYLTAEKFM SGFVSALTQQ
     NSIAFKERLR NIDVLIIDDV QFLQGKSIQQ EFCHTLNSLI DAGKQVVVAA DRPPSDLETL
     DERVLSRFKG GLCVDIGPLD EELRMKILEA RIAAAQEAQP NFHVPPAVMS YIAKTIVTNG
     RDLEGAVNRL LAHSTLNGAP LCVETAENAI RDLVRSAEPK RVKIDDIQKL VASHYNISRA
     DILSSRRTAN VVRPRQIAMY LSKVLTLRSL PEIGRRFGGR DHTTVLHAVR KVEELASKDK
     SLSEVIELLK RMLAE
//
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