ID A0A177QH59_9PLAN Unreviewed; 892 AA.
AC A0A177QH59;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=AYO44_10160 {ECO:0000313|EMBL:OAI47131.1};
OS Planctomycetaceae bacterium SCGC AG-212-F19.
OC Bacteria; Planctomycetota; Planctomycetia; Planctomycetales;
OC Planctomycetaceae.
OX NCBI_TaxID=1799658 {ECO:0000313|EMBL:OAI47131.1, ECO:0000313|Proteomes:UP000186541};
RN [1] {ECO:0000313|Proteomes:UP000186541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC AG-212-F19 {ECO:0000313|Proteomes:UP000186541};
RA Choi J., Stepanauskas R., Howe A.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAI47131.1}.
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DR EMBL; LSTD01000270; OAI47131.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177QH59; -.
DR Proteomes; UP000186541; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR CDD; cd04862; PaeLigD_Pol_like; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014143; NHEJ_ligase_prk.
DR InterPro; IPR033651; PaeLigD_Pol-like.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000186541};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 330..423
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 194..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 892 AA; 99200 MW; B95932ED5B362241 CRC64;
MSLTEYQCKR HFKRTPEPAG KRAAKPGHLF VVQKHQARQL HYDFRLELDG VLKSWAVPKG
PSLDPSVKRL AVQVEDHPVE YGSFEGIIPP GEYGGGTVML WDQGEWEPVG DPEDGYRAGR
LKFKLHGAKL RGGWMLVHTG GGASGRDKRQ WLLIKERDEE ATPSKDGDIL EHMPLSVATG
RSLEEIAADR HRVWTSKAKS PMQSARQTPR KKSATERSQR TSVAAAIPGR KTRSLPSRVA
VQLATLAAEA PEGDEWLHEI KLDGYRMICR IANGRVAFMS RNHQDWTARF PALVAAAQRL
PIRQAIFDGE VVAVRPDGST NFQDLQNAFR DVRTDQLYYF VFDILHLDGH DLAGLPLAER
KRLLAKLLGE TGVPPTIRLS EHIEGNGPAF FKKVCAMGLE GIISKRRDQP YRPGRGYDWL
KVKCMQTGEF VIGGFTEPTG GRAKFGALLL GYYNAKGELV YAGKVGTGFD NRTLHSLFAR
LKPLEQDESP FSNLPRGGPK THWVEPRLVA QVTFGGWTRD GLLRHPSFQG LREDKPAAEV
TRDLAIPVSS AMRRQRSSKS PPQGVNGRNG RDRRMKKSGP NGAANGETGY DANEQRLAGV
RLTSPDKILY PEQRITKLEL AQYYQAIAEW MLPHIADRPL VLVRCPEGRG KACFYQKHPS
PGTPDTLRRI PVREKAKTED YVIVDDVAGL ISLAQIGALE IHAWGARADN LEQPDRLIFD
LDPDPSVSWS RVVDSAGAVR DFLQELGLTS FVKTTGGKGL HLVVPILRRQ DWEEVKAFCK
RVADAIVAAD AARYTANMSK AARPGKIFID YLRNARGATA VVPYSPRARP GAPVSVPLTW
KELSPRIGPA QFTIRNIMDR LRSLKRDPWE EIASVRQGLA GPIKKLQTVF TS
//
