ID A0A177RAM3_9BACT Unreviewed; 708 AA.
AC A0A177RAM3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OAI56818.1};
GN ORFNames=AYO50_02360 {ECO:0000313|EMBL:OAI56818.1};
OS Acidobacteria bacterium SCGC AG-212-P17.
OC Bacteria; Acidobacteriota.
OX NCBI_TaxID=1803033 {ECO:0000313|EMBL:OAI56818.1, ECO:0000313|Proteomes:UP000078500};
RN [1] {ECO:0000313|Proteomes:UP000078500}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC AG-212-P17 {ECO:0000313|Proteomes:UP000078500};
RA Choi J., Yang F., Williams R., Stepanauskas R., Cardenas E., Flater J.,
RA Garoutte A., Hofmockel K., Tiedje J., Gelder B., Howe A.;
RT "Refsoil: a soil-specific genomic reference database.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAI56818.1}.
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DR EMBL; LSTK01000038; OAI56818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177RAM3; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000078500; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309:SF51; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000078500}.
FT DOMAIN 302..479
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 482..575
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 610..695
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 708 AA; 76371 MW; 28889AD306B4D1CE CRC64;
MSDLVQLSKD NDIAIIMINN PPVNALSPGV PEGISEAIEQ IDKDATVKAA VLIGGGKTFV
AGADIKEFGK MTSGKTRGGI PFLPLLMRIE DCSKPVVMAI HGTAFGGGLE LAMAGHYRVA
APSALVGQPE VKLGIIPGAA GTQRLPRLAG VAKAVEMCAG GDPMKAKEAL SLGIVDKLID
GDLLSGAVAF AREVAGKPAR KTRERNEKLG SAEQNAAIFA AARDAARKKA RGLMAPLAAI
DAVEAATKLP FDQGVEAERK LFTECLFSDQ SKAMIHVFFG EREVAKIPDV PKETPTIPVN
TAAVIGAGTM GGGIAMNFAN AGIPVLLKET DQAALDRGIN TIRKNYDNSV KKGRFTQQQM
DDRMKLIKPT LTYDGFESVD MVIEAVFEGM ALKKQVFGDL DKICKQGAIL ASNTSTLSID
EIASATTRPE SVIGTHFFSP ANVMRLLEIV RGKATSKEVI ATCMQLSKKL GKVGVLVGNC
RGFVGNRMFG PYRREAQFLV EEGAGIEAID RSMYDFGAAM GPLAVGDLAG LDVGWRIRKE
FKHLEKPGVR QPLAEDRLCE MGRYGQKTGA GWYKYDENRR AIFDPTVEEN VRKWAAETGV
KQHAISKEEI VDRLIYALVN EGARILEEGY ALRAVDIDII YLTGYGFPAH RGGPMWYADT
VGLKKVYERV CEFHKQHGEL WEPAPLLKRL AEEGKGFADF NNQSSVAA
//