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Database: UniProt
Entry: A0A177RAM3_9BACT
LinkDB: A0A177RAM3_9BACT
Original site: A0A177RAM3_9BACT 
ID   A0A177RAM3_9BACT        Unreviewed;       708 AA.
AC   A0A177RAM3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OAI56818.1};
GN   ORFNames=AYO50_02360 {ECO:0000313|EMBL:OAI56818.1};
OS   Acidobacteria bacterium SCGC AG-212-P17.
OC   Bacteria; Acidobacteriota.
OX   NCBI_TaxID=1803033 {ECO:0000313|EMBL:OAI56818.1, ECO:0000313|Proteomes:UP000078500};
RN   [1] {ECO:0000313|Proteomes:UP000078500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCGC AG-212-P17 {ECO:0000313|Proteomes:UP000078500};
RA   Choi J., Yang F., Williams R., Stepanauskas R., Cardenas E., Flater J.,
RA   Garoutte A., Hofmockel K., Tiedje J., Gelder B., Howe A.;
RT   "Refsoil: a soil-specific genomic reference database.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAI56818.1}.
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DR   EMBL; LSTK01000038; OAI56818.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A177RAM3; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000078500; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309:SF51; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078500}.
FT   DOMAIN          302..479
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          482..575
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          610..695
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   708 AA;  76371 MW;  28889AD306B4D1CE CRC64;
     MSDLVQLSKD NDIAIIMINN PPVNALSPGV PEGISEAIEQ IDKDATVKAA VLIGGGKTFV
     AGADIKEFGK MTSGKTRGGI PFLPLLMRIE DCSKPVVMAI HGTAFGGGLE LAMAGHYRVA
     APSALVGQPE VKLGIIPGAA GTQRLPRLAG VAKAVEMCAG GDPMKAKEAL SLGIVDKLID
     GDLLSGAVAF AREVAGKPAR KTRERNEKLG SAEQNAAIFA AARDAARKKA RGLMAPLAAI
     DAVEAATKLP FDQGVEAERK LFTECLFSDQ SKAMIHVFFG EREVAKIPDV PKETPTIPVN
     TAAVIGAGTM GGGIAMNFAN AGIPVLLKET DQAALDRGIN TIRKNYDNSV KKGRFTQQQM
     DDRMKLIKPT LTYDGFESVD MVIEAVFEGM ALKKQVFGDL DKICKQGAIL ASNTSTLSID
     EIASATTRPE SVIGTHFFSP ANVMRLLEIV RGKATSKEVI ATCMQLSKKL GKVGVLVGNC
     RGFVGNRMFG PYRREAQFLV EEGAGIEAID RSMYDFGAAM GPLAVGDLAG LDVGWRIRKE
     FKHLEKPGVR QPLAEDRLCE MGRYGQKTGA GWYKYDENRR AIFDPTVEEN VRKWAAETGV
     KQHAISKEEI VDRLIYALVN EGARILEEGY ALRAVDIDII YLTGYGFPAH RGGPMWYADT
     VGLKKVYERV CEFHKQHGEL WEPAPLLKRL AEEGKGFADF NNQSSVAA
//
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