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Database: UniProt
Entry: A0A177U540_9BASI
LinkDB: A0A177U540_9BASI
Original site: A0A177U540_9BASI 
ID   A0A177U540_9BASI        Unreviewed;       794 AA.
AC   A0A177U540;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   31-JUL-2019, entry version 16.
DE   RecName: Full=Urease domain-containing protein {ECO:0000259|PROSITE:PS51368};
DE   Flags: Fragment;
GN   ORFNames=A4X09_g7362 {ECO:0000313|EMBL:OAJ10649.1};
OS   Tilletia walkeri.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Exobasidiomycetes; Tilletiales; Tilletiaceae; Tilletia.
OX   NCBI_TaxID=117179 {ECO:0000313|EMBL:OAJ10649.1, ECO:0000313|Proteomes:UP000078113};
RN   [1] {ECO:0000313|EMBL:OAJ10649.1, ECO:0000313|Proteomes:UP000078113}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DAOM 236422 {ECO:0000313|EMBL:OAJ10649.1,
RC   ECO:0000313|Proteomes:UP000078113};
RA   Nguyen H.D., Samba Siva P., Cullis J., Levesque C.A., Hambleton S.;
RT   "Draft genome sequence of Tilletia indica and Tilletia walkeri.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001222-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR001222-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR001222-50}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OAJ10649.1}.
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DR   EMBL; LWDG01000487; OAJ10649.1; -; Genomic_DNA.
DR   EnsemblFungi; OAJ10649; OAJ10649; A4X09_g7362.
DR   OrthoDB; 183108at2759; -.
DR   Proteomes; UP000078113; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0043419; P:urea catabolic process; IEA:InterPro.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR008221; Urease.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001222; Urease; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 2.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000078113};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078113}.
FT   DOMAIN      418    794       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    609    609       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       423    423       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       425    425       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       506    506       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       506    506       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       535    535       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       561    561       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       649    649       Nickel 1. {ECO:0000256|PIRSR:PIRSR001222-
FT                                51}.
FT   BINDING     508    508       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     506    506       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR001222-50}.
FT   NON_TER     794    794       {ECO:0000313|EMBL:OAJ10649.1}.
SQ   SEQUENCE   794 AA;  85018 MW;  B82857D6A33BC90C CRC64;
     MHLLPRERDK LLLHQAGTLA QKRLARGVRL NQAEATALIA SVLQEKIRDG QHSVAQLMQH
     GKTMLGRTHV MPGVAELLHE VMVEGAFQDG TFLVTVHDPI CTEHGDLSAA LYGSFFPIPS
     AELFKPRPGI DDVALVLPGA TVVRKSAPNI VLSPGRSRVR VKVTNTGDRP IQVGSHYLFT
     ETNPALSFPR LLALGRRLDI PAGTAVRFEP GDTKTVSLVT IGGNKLMSGG NSLFPGPLSS
     MGLTNSTVRS SMRERLRLTG FKDEDVVDES VIVDAFLGRV TGPEVLPCAI SREAYAALYG
     PTVGDRVRLA DSNLWIEVER DLTHYGDECK FGGGKVLRDG MGQASGRKDA ETLDCVIMNA
     LIVDWWGIVK ADVGIKEGHV AAIGKAGNPD TMEGVTEGMI VGSCTEVIAG EKLILTAGAI
     DAHVHYICPD LCEEALATGI TTLIGGGTGP TSGTSATTCT PGKDNLKAMI RATDDIPLNF
     CFTGKGNDSG TVGLEEQIKA GCGGLKLHED WGSTPAAIDT CLTVCDKYDV QCNIHTDTLN
     ESSFVEGTLA AIKGRTIHTY HSEGAGGGHA PDIISVCGEP NVLPSSTNPT RPYAMNTLDE
     HLDMLMVCHH LSRDIVEDVA FADSRIRAET VAAEDVLQDE GAISMISSDS QAMGRIGEVV
     SRTWRTAAKM RDLKGPLQGK GEGEQDGEGR DNFRVKRYVS KYTINPAIVH GMSHYIGSIE
     PGKWADLVLY RPENFGVKPE IVIKGGQIAW AQMGDANASI PTVQPIYGRP MFATKPQAAH
     ANSILWVSDV SLKN
//
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