ID A0A177WFB4_BATDL Unreviewed; 3933 AA.
AC A0A177WFB4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0008006|Google:ProtNLM};
GN ORFNames=BDEG_22029 {ECO:0000313|EMBL:OAJ38061.1};
OS Batrachochytrium dendrobatidis (strain JEL423).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=403673 {ECO:0000313|EMBL:OAJ38061.1, ECO:0000313|Proteomes:UP000077115};
RN [1] {ECO:0000313|EMBL:OAJ38061.1, ECO:0000313|Proteomes:UP000077115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL423 {ECO:0000313|EMBL:OAJ38061.1,
RC ECO:0000313|Proteomes:UP000077115};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Cuomo C., Devon K., Jaffe D., Butler J.,
RA Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E., Brockman W.,
RA Young S., LaButti K., Sykes S., DeCaprio D., Crawford M., Koehrsen M.,
RA Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J.,
RA O'Leary S., Kodira C., Zeng Q., Yandava C., Alvarado L., Longcore J.,
RA James T.;
RT "The Genome Sequence of Batrachochytrium dendrobatidis JEL423.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAJ38061.1, ECO:0000313|Proteomes:UP000077115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL423 {ECO:0000313|EMBL:OAJ38061.1,
RC ECO:0000313|Proteomes:UP000077115};
RA Cuomo C.A., Farrer R.A., James T., Longcore J., Birren B.;
RT "Lineage-specific infection strategies underlie the spectrum of fungal
RT disease in amphibians.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS022301; OAJ38061.1; -; Genomic_DNA.
DR STRING; 403673.A0A177WFB4; -.
DR VEuPathDB; FungiDB:BDEG_22029; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000077115; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000077115}.
FT DOMAIN 854..1259
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1461..1645
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1813..1936
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2180..2269
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2345..2605
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2619..2962
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2993..3213
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3457..3572
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3607..3745
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3753..3926
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 779..839
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2849..2911
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3933 AA; 448523 MW; 3E60F495DA4D2182 CRC64;
MSTNSPDPIH VTYSNEFGVS DKEALQQPHL PPVAETAVPP EIILRKRSLT LRELVKASQD
ARVNETEIPP ELLSKIKVRP PVPKRYTYHS HTIDEPWMRL ENARNYSPGA SIAAEVGATA
GGTKLAKKHH SHEALNNHDK SPVKLTCTAF RDRLIEFLIE QQNSKSALDE DDIASIMLVN
LPKEFVPDPR TYRILQRLIA DEATDLEDEC IVEAFYDYFG SSVKAVTVSD LEQSWVNNIL
RAIPRNLKTS YPAQISHLLE EVQESFRESG KNSAVHHILK KPAHLQQQQL LDTYQKQPAF
SETLSNPSPW HKSFVENKAK IERLLFISNH ALCHLMQTAS YFSHLRYVDI KEMRSQRDAF
RISSYRSLML VQAEKCRTKI WHGWLAIILK NFAETYIRKR KREVLPQKPS EPFFRCAQML
ICNQLQAIMV ESINDYVHMF SFYPIALSNS DAVYVKGKNL KPPRFSVRLT FTIKARVIEF
DPPFNEIEDA VLDGLGFLVS TVDTAPRIES AIYGHNGEAL LAMEFPSIQT VLQNTHATSV
DSDGNPAFRM SIGDVEQIKL YVEDSLIEAT NSHLKKYVNN CFAIAAEYLT RYDPYIELFS
SEIDCQVEEF FSTAHSFEEH VEQIEKYKSI VNEILSHPRR VELVLIDLIT EDLHRIFVAR
ANSLAARFIT KITEQSIEHQ QQICARYEAI EERALQIPEG FKEMAEQMEY MQKTLEDELP
LLLLELEESR RKLMHIFNYS LLNDEHIKLN SKTFTWPAKI IPILEQHNII IGAAREKSEE
NLRERRTKFE LELEEIRVQV DELKEVGDLD EMPFYVKKVQ ALAKQLQAAQ DSVAGFNKEE
QLFGWPETSY PQRKQIMAAL EPFQALYTTA VTFQKSYKKW MDGNLLELDA EQIEQEVDSL
KRDMYRVLGA LVQDSAPQNI AKAVKEKIDE FMVNIPLIHV LCNPGMRDRH WTKMSAAAEF
EIRPDGSASL RKMLKMNLEQ FLVPFQEISD FASKEYTLEK NMSKMFQEWE PLEFILIAYR
ETGTHILASV DEAQQLLDDQ IVKTQSMRGS PYIKPFEQQI KEWEHKLLTT QEIIDEWLKV
QATWLYLEPI FSSEDIMNQM PEESKKFKMV DYSWRKTMCV VSQDRHILKI TTIPNLLEEL
QKNNIMLEEI LKGLNSYLEV KRLFFPRFFF LSNDEMLEIL SETKDPTRVQ PHLKKCFEGV
ATLEFDEKLD IISLYSSEKE RLALTKKVST VDAKGTVEKW LRDVENAMLS SLHSIIKAAY
LAYPNSPREK WVLEWPGQVV ICVSQIYWTL AVEKAILEGK RGIEQHLMQL NRDLNETIKL
VRGELSKMAR YTLGALVVID VHARDVIANM AHTENIKDTN DFAWLSQLRY YWENNNVMVK
MINAQKRYGY EYLGNSARLV ITPLTDRCYR TLFGALHLNL GGAPEGPAGT GKTETTKDLA
KALAKQCVVF NCSDGLDYLA MGYAGRSELP DNLKALFRTV AMMVPDYSLI AEITLYSFGF
IEARNLARKI AATYRLCSEQ LSSQDHYDYG MRAVKSVLTA AGNLKLKYPD EDESVLVLRS
IIDVNLPKFL SQDIALFKGI ATDLFPGVCL PKSDYVKLED AIQIACQRMN LQMVPAFVEK
VFQLYEMMLV RHGYMLVGEP FSGKTTAYRV LGEALNIIAA NEPAGTDEWL SVQYKAINPK
SITMGQLYGQ FDPISHEWTD GVLATSFRSY ASSTSPDRKW VIFDGPVDAI WVENMNTVLD
DNKKLCLMSG EIIQLSNTMS LVFEVMDLSV ASPATVSRCG MVYLEPERLG WRPLLQSWLN
SITYLSATIK EYISQLFETF VQPSLTFVRK DCKELSPTTD IGLVNSLLRL FDSTFDDFRK
RGIIEENDQD SLWEQRIQCR FLFCMAWTIG GSIDTPSQLK FDHMMRQCIY KMQPPLKLEL
PIEGTIYDYL YQSNQQESDS DFSDSTKQLQ HNKDAWIPWL QTIPAIHLPT NSDFNDIIIP
TKDTARYNYL MDLMILHDIP LLLVGPTGTG KSKYISSKLL NGISRDMFLP LAINFSARTS
ANQVQDLVMA KLDKRRKGVF GAPVGKRYIV FIDDLNMPAK EQYGAQPPIE LFRQWIDHGN
WYDRKDTSRI ELVDIQLIAA MGPPGGGRNL ITPRFQRHFN QVVINSFDDA TMFRIFNSIL
EWHFSRFEFV EEIRNISYIL VDSTMSVYQW AVKNLLPTPA KTHYTFNLRD FAKVIQGLVL
SRPTHFGSDT SMLRLWTHEV YRVYYDRLVA DEDRSNMFAF VMSTINEKFK KDPNIVFAHV
ATGDKVDESP TVVDDDMRSV FFGDFVTCAS PGAETNYIEV ENFDTISEIC KAQLAEYNQV
KKTKLDLVLF RFAIEHVSKI CRILKLPGGN ALLVGVGGSG RQSLTRLSAF ISKYQVFQIE
ISKSYSRVEW RDDLKKILTM TGVENQKTVF LFPDTQIREE SFIEDVNSLL NAGDVPNLFA
ADERQAIVEK LANDAVEDGK AADASPMAIY SYFVDRVKKN LHIVLCMSPI GDAFRARLRQ
FSSIVNCCTI DWFQAWPNDA LQAVAKQFLQ DTNLDTSIFD KVIAMCQYFH QYAIALSQRY
LVALSRHNYV TPTSYLELLN AYKTLLNQKF QEISMVRKRY AGGLDKLQFA AEQIARMQVD
LKELQPQLLK TSEETIEMLA KIEKESVEVE STRKTVASDE AIASFKAEQS AAMKNECEND
LAEALPLLNA ALAALDTLKK TDIDLVKSMK NPPDGVKLVM EAVCVMKDIK PEKIPDPSGS
GRMVLDYWKP SLKMLGDPQF LNSLKSFDKD DIPPHVIKKI RQTFIPNPEF KPEKVRNASS
AAEGLCSWIG AMEAYDRVAK IVAPKQEALA KAEAELAETM KGLDEKRALL KEIMDRLQSL
NNNLQALTEK KARLEKEVKS CEDQLDRAQK LLGGLGGEKH RWTEITKQLD GTLYNLSGDV
LISAGVAAYL GAFTKLYRQE CVASWVETLK KEKIPCTDAF SLIKVLGDPI KIREWNIAGL
PSDAFSVDNG IIVQNARRWP LMIDPQGQAN KWVKNMEKNH KLVIIKLTDT DFVRNLENAI
TFGLPVLLEN LKEELDPILD TILQKQTFKS GGATCIRLGD AVIEYAESFR LYMTTKLRNP
HYFPETSVKV SLLNFMITPE GLEDQLLGIV VAKERPELEE EKVQLIFQSA ENKKKLQEIE
DQILQILSSA EGNILENETA IEVLSSSKVL SVELFDKQRV AEETECKIDE TRESYRPIAN
HSAVLYFCIA DLTNIEPMYQ YSLVWFMDLF VISISQSNKS SVVKRRLKNL ESYFTYSLYC
NVCRSLFEKD KLLFSFLLCI TILRKYNDLD EAEFAHFMTG GIGLGGQCIP NPDPSIISEK
GWTEIGRLSD LPAFKGLIQE FSLSGWKQVI DTNDLLEVKF PGKWNTINDF QHLLIIRALR
PEKIVPSVQE FVKAKLGHKF IEPPIFDLAG SYEDSSNHSP LIFILSPGVD PMAQLIKFAE
DQGFGGQKCQ SISLGQGQGP IAAQMIREAQ KGGTWVVLQN CHLAVSWLST LEKIVDDMTS
GASVHRDFRL WLTSYPSPKF PSSILQIGVK MTNEPPKGIK ANILKSYLSD PISNEKFFAA
CKKPAEWEKL LFGLCTFHAI VQERRNFGPL GWNIPYEFNE SDLRISIRQL QMFLDEYAEI
PFKAIIYLTG ECNYGGRVTD EWDRRTLTNL LTTFYCPAIV EDNGYRFSPS GVYYAPAKGK
YDQYLEYVRS LPLNQSPEIF GIHDNGDIAR QLAETRQLFE SVIQTQGNTF GSSQGNGQKS
SEEIIIEISS DILSRIPAAF NLEEAIKRYP VDYNESMNTV LVQEMIRFNK LIQVVLGGLA
NVQKAIKGLV VNSSELEEVC KSILVGRVPA MWAARSYPSL KPLGGYVNDL IARIKFFQTW
LEHGSPVVFW MSGFFFTQSF ITALLLESMV WYG
//
