ID A0A177WRM4_BATDL Unreviewed; 639 AA.
AC A0A177WRM4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN ORFNames=BDEG_25773 {ECO:0000313|EMBL:OAJ42305.1};
OS Batrachochytrium dendrobatidis (strain JEL423).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=403673 {ECO:0000313|EMBL:OAJ42305.1, ECO:0000313|Proteomes:UP000077115};
RN [1] {ECO:0000313|EMBL:OAJ42305.1, ECO:0000313|Proteomes:UP000077115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL423 {ECO:0000313|EMBL:OAJ42305.1,
RC ECO:0000313|Proteomes:UP000077115};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Cuomo C., Devon K., Jaffe D., Butler J.,
RA Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E., Brockman W.,
RA Young S., LaButti K., Sykes S., DeCaprio D., Crawford M., Koehrsen M.,
RA Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J.,
RA O'Leary S., Kodira C., Zeng Q., Yandava C., Alvarado L., Longcore J.,
RA James T.;
RT "The Genome Sequence of Batrachochytrium dendrobatidis JEL423.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAJ42305.1, ECO:0000313|Proteomes:UP000077115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL423 {ECO:0000313|EMBL:OAJ42305.1,
RC ECO:0000313|Proteomes:UP000077115};
RA Cuomo C.A., Farrer R.A., James T., Longcore J., Birren B.;
RT "Lineage-specific infection strategies underlie the spectrum of fungal
RT disease in amphibians.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR EMBL; DS022307; OAJ42305.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177WRM4; -.
DR STRING; 403673.A0A177WRM4; -.
DR VEuPathDB; FungiDB:BDEG_25773; -.
DR eggNOG; KOG0995; Eukaryota.
DR Proteomes; UP000077115; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW Reference proteome {ECO:0000313|Proteomes:UP000077115}.
FT DOMAIN 227..291
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 15..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 267..294
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 319..360
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 466..493
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 72541 MW; 86C73A046782B067 CRC64;
MSRLSMAPGM NTRLSMLSSQ QQRSSKPGGL VGLSDTMAGL SVGQSRPSDT RRTSTINGNG
SARMSLGRQS MGFGGRPSLS SVSLSGQASS ITKDPRPLKE KQWQTKAIKQ LVSFLAQTGC
PVPISAKKLT APSSKDFADV FKFLYRKLEP NHEFKSKIEE ELLSLLRTLR YPFAEQINKS
QLFSIGSPHA WPTFLGILHW LMEEIMCCIE FDEQSQIDDN NDTMGDSRQP EKIFHDYVIR
TYIAFLEGSD DFDAIDRELM GSFDRKNEVT IRDVERLRRE HQALEEEMAV LTQGESPLEA
LTRENGILES DKEKFRTYIT HVEGKEQKLN ENLLSLKQEL DIQAEEIACL TNEKTELQQT
VDAQDISPAD VDRMNAERDQ LALSLQTVST KLETANKIVW EKEIALQKRM DQLEKVVQDY
NSQAFKLGLI GSRSADLAPL AKELELYIQA DTQDHMVSVD LKGVVKTTLQ RLKERYNAAL
HKAQDDMLEL QETLDQLVWT QTRDEEELLS MQSRITFLNH RYNEEKEHVT LTTTAMNDDI
EHFERQIQKL KVESNAMMFA VQQKGQTVTI EYEELSRKYT EQKEKALNQL IRGLQDVFGM
QTGVAAAIEE LSRQANEALT EATNYTSNLI SSEDTVIEV
//
