ID A0A177WSD5_BATDL Unreviewed; 791 AA.
AC A0A177WSD5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=asparaginase {ECO:0000256|ARBA:ARBA00012920};
DE EC=3.5.1.1 {ECO:0000256|ARBA:ARBA00012920};
GN ORFNames=BDEG_26145 {ECO:0000313|EMBL:OAJ42726.1};
OS Batrachochytrium dendrobatidis (strain JEL423).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=403673 {ECO:0000313|EMBL:OAJ42726.1, ECO:0000313|Proteomes:UP000077115};
RN [1] {ECO:0000313|EMBL:OAJ42726.1, ECO:0000313|Proteomes:UP000077115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL423 {ECO:0000313|EMBL:OAJ42726.1,
RC ECO:0000313|Proteomes:UP000077115};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Cuomo C., Devon K., Jaffe D., Butler J.,
RA Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E., Brockman W.,
RA Young S., LaButti K., Sykes S., DeCaprio D., Crawford M., Koehrsen M.,
RA Engels R., Montgomery P., Pearson M., Howarth C., Larson L., White J.,
RA O'Leary S., Kodira C., Zeng Q., Yandava C., Alvarado L., Longcore J.,
RA James T.;
RT "The Genome Sequence of Batrachochytrium dendrobatidis JEL423.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAJ42726.1, ECO:0000313|Proteomes:UP000077115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL423 {ECO:0000313|EMBL:OAJ42726.1,
RC ECO:0000313|Proteomes:UP000077115};
RA Cuomo C.A., Farrer R.A., James T., Longcore J., Birren B.;
RT "Lineage-specific infection strategies underlie the spectrum of fungal
RT disease in amphibians.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DS022308; OAJ42726.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177WSD5; -.
DR STRING; 403673.A0A177WSD5; -.
DR VEuPathDB; FungiDB:BDEG_26145; -.
DR eggNOG; KOG0503; Eukaryota.
DR Proteomes; UP000077115; Unassembled WGS sequence.
DR GO; GO:0004067; F:asparaginase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009066; P:aspartate family amino acid metabolic process; IEA:UniProt.
DR CDD; cd08963; L-asparaginase_I; 1.
DR Gene3D; 3.40.50.40; -; 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.1170; L-asparaginase, N-terminal domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036152; Asp/glu_Ase-like_sf.
DR InterPro; IPR006034; Asparaginase/glutaminase-like.
DR InterPro; IPR027475; Asparaginase/glutaminase_AS2.
DR InterPro; IPR040919; Asparaginase_C.
DR InterPro; IPR027473; L-asparaginase_C.
DR InterPro; IPR041725; L-asparaginase_I.
DR InterPro; IPR027474; L-asparaginase_N.
DR InterPro; IPR037152; L-asparaginase_N_sf.
DR PANTHER; PTHR11707:SF28; 60 KDA LYSOPHOSPHOLIPASE; 1.
DR PANTHER; PTHR11707; L-ASPARAGINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00710; Asparaginase; 1.
DR Pfam; PF17763; Asparaginase_C; 1.
DR PIRSF; PIRSF001220; L-ASNase_gatD; 3.
DR PIRSF; PIRSF500176; L_ASNase; 3.
DR PRINTS; PR00139; ASNGLNASE.
DR SFLD; SFLDS00057; Glutaminase/Asparaginase; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00870; Asparaginase; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF53774; Glutaminase/Asparaginase; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS00917; ASN_GLN_ASE_2; 1.
DR PROSITE; PS51732; ASN_GLN_ASE_3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000077115}.
FT DOMAIN 66..331
FT /note="L-asparaginase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00710"
FT DOMAIN 353..408
FT /note="Asparaginase/glutaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17763"
FT REPEAT 574..606
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 674..706
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT ACT_SITE 231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10100"
FT BINDING 200
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001220-2"
FT BINDING 231..232
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001220-2"
SQ SEQUENCE 791 AA; 86137 MW; 11965F75B85FC3EC CRC64;
MSAHVPESGT VQMNQNNIPS VMPVLLNAST VESPGVQEQP VFNNDAVNVQ VESDIVDSMV
SADTSRVLLI YTGGTIGMQN SHPHGYRPVK GYLTQTLANM LRFHTQTAEG WAHPHNYGHG
ASTPIHSVPR FTNLVNVILE DSNVGMSTAN SSTTSNPSNT RVVNGTPVKQ IQLPALISPP
SLYGKRINYS ILEYEPLLDS SNMTMTDWVK IATNIEVNYR LFDAFIILHG TDTMAYTASA
LSFMLEDLGK TVIVTGSQVP LAEVRNDAVD NLLGALTIAG HFVIPEVGLF FDNKLFRGNR
SSKVNAVDFN AFDSPNLRPL VNVGINIDVS WVDIWRPKRI AEFRTFKAMN PSVATLRLFP
GITEATVRAF LSPPIAGVVL ETYGSGNAPS NRHELLKAFK EACDRGKALT AIGIVPGADM
TPECALTKLS YLLAKYSDVH ILRRLMRKSL RGELTIPVRR QRFTYFMRPS GSTAISSHGN
SISSLLAMLG VHRPIHSTSR RPSELLEQDS YSSSLGQQFG ESGAETDDPE AYSSNLENVL
VPLLLCQAVR AVDLSGLTTV LNEYEHMVNV QDYDGRGPLH VAASDGQRDC VELLLRHGAN
VHLRDNFGHS ALFDCVSGGH VEVASLLRKA GSHFSLEEET DVTWLLCKSV VNGDVSRVRM
LMECGADMNK PVQDGRTALH LAVSHNHIAL LQLIIHAARE IQLSQHLASC TVQSPISPDV
PPLSMHSNLS LSNLMDMSRG LSSSALPHTT GVNLEPVDGW GNTPLDDAVR LGRDEAAAIL
RDALILSKTD E
//
