ID A0A177Y755_9NOCA Unreviewed; 210 AA.
AC A0A177Y755;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_00739, ECO:0000256|HAMAP-Rule:MF_01954};
DE Includes:
DE RecName: Full=Urease subunit gamma {ECO:0000256|HAMAP-Rule:MF_00739};
DE EC=3.5.1.5 {ECO:0000256|HAMAP-Rule:MF_00739};
DE AltName: Full=Urea amidohydrolase subunit gamma {ECO:0000256|HAMAP-Rule:MF_00739};
DE Includes:
DE RecName: Full=Urease subunit beta {ECO:0000256|HAMAP-Rule:MF_01954};
DE AltName: Full=Urea amidohydrolase subunit beta {ECO:0000256|HAMAP-Rule:MF_01954};
GN Name=ureA {ECO:0000256|HAMAP-Rule:MF_00739};
GN Synonyms=ureB {ECO:0000256|HAMAP-Rule:MF_01954};
GN ORFNames=A3K89_11975 {ECO:0000313|EMBL:OAK51325.1};
OS Rhodococcus kyotonensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=398843 {ECO:0000313|EMBL:OAK51325.1, ECO:0000313|Proteomes:UP000077519};
RN [1] {ECO:0000313|EMBL:OAK51325.1, ECO:0000313|Proteomes:UP000077519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KB10 {ECO:0000313|EMBL:OAK51325.1,
RC ECO:0000313|Proteomes:UP000077519};
RA Jeong H., Hong C.E., Jo S.H., Park J.M.;
RT "Genome sequence of Rhodococcus kyotonensis KB10.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000242, ECO:0000256|HAMAP-
CC Rule:MF_00739};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000256|ARBA:ARBA00004897,
CC ECO:0000256|HAMAP-Rule:MF_00739}.
CC -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha)
CC subunits. Three heterotrimers associate to form the active enzyme.
CC {ECO:0000256|HAMAP-Rule:MF_00739}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00739}.
CC -!- SIMILARITY: Belongs to the urease beta subunit family.
CC {ECO:0000256|HAMAP-Rule:MF_01954}.
CC -!- SIMILARITY: Belongs to the urease gamma subunit family.
CC {ECO:0000256|HAMAP-Rule:MF_00739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAK51325.1}.
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DR EMBL; LVHI01000039; OAK51325.1; -; Genomic_DNA.
DR RefSeq; WP_068431161.1; NZ_LVHI01000039.1.
DR AlphaFoldDB; A0A177Y755; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000077519; Unassembled WGS sequence.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; Urease, beta subunit; 1.
DR Gene3D; 3.30.280.10; Urease, gamma-like subunit; 1.
DR HAMAP; MF_01954; Urease_beta; 1.
DR HAMAP; MF_00739; Urease_gamma; 1.
DR InterPro; IPR002019; Urease_beta-like.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR012010; Urease_gamma.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR NCBIfam; TIGR00192; urease_beta; 1.
DR NCBIfam; TIGR00193; urease_gam; 1.
DR PANTHER; PTHR33569; UREASE; 1.
DR PANTHER; PTHR33569:SF1; UREASE; 1.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; Urease, beta-subunit; 1.
DR SUPFAM; SSF54111; Urease, gamma-subunit; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00739};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00739};
KW Reference proteome {ECO:0000313|Proteomes:UP000077519}.
SQ SEQUENCE 210 AA; 22588 MW; E90E58A03741E0BB CRC64;
MRLTPHEQDR LLLSYAAELA RKRQARGRKL NHPEAIALIT DHLLEGARDG RSVAELMVSG
REVLTADDVI GGVPELLPEV QVEATFPDGT KLITVHEPIS PKRGDGHLVP GEIITEDGTI
EINEGADVVT IDVVNTGDRP VQVGSHVHFP QSNEALDYDR AAAYGRRLDI PAGTAVRFEP
GIAMTVQLVP LAGGREVHGL SMNPPGKLDA
//
