ID A0A178AE45_9PLEO Unreviewed; 1221 AA.
AC A0A178AE45;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Coatomer subunit alpha {ECO:0000256|PIRNR:PIRNR003354};
GN ORFNames=IQ06DRAFT_340315 {ECO:0000313|EMBL:OAK94737.1};
OS Stagonospora sp. SRC1lsM3a.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Massarinaceae; Stagonospora.
OX NCBI_TaxID=765868 {ECO:0000313|EMBL:OAK94737.1, ECO:0000313|Proteomes:UP000077206};
RN [1] {ECO:0000313|EMBL:OAK94737.1, ECO:0000313|Proteomes:UP000077206}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRC1lsM3a {ECO:0000313|EMBL:OAK94737.1,
RC ECO:0000313|Proteomes:UP000077206};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network.
CC {ECO:0000256|PIRNR:PIRNR003354}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR003354}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR003354}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR003354}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR003354};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KV441724; OAK94737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A178AE45; -.
DR STRING; 765868.A0A178AE45; -.
DR InParanoid; A0A178AE45; -.
DR OrthoDB; 20819at2759; -.
DR Proteomes; UP000077206; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:UniProtKB-UniRule.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd22948; Coatomer_WDAD_alpha; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR047312; Coatomer_alpha_WD-assoc_reg.
DR InterPro; IPR016391; Coatomer_asu.
DR InterPro; IPR010714; Coatomer_asu_C.
DR InterPro; IPR006692; Coatomer_WD-assoc_reg.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19876; COATOMER; 1.
DR PANTHER; PTHR19876:SF1; COATOMER SUBUNIT ALPHA; 1.
DR Pfam; PF04053; Coatomer_WDAD; 1.
DR Pfam; PF06957; COPI_C; 1.
DR Pfam; PF00400; WD40; 5.
DR PIRSF; PIRSF003354; Coatomer_alpha_subunit; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR003354};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR003354};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR003354};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR003354};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR003354};
KW Reference proteome {ECO:0000313|Proteomes:UP000077206};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR003354};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 53..94
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 95..136
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 137..178
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 211..252
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 255..296
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 350..778
FT /note="Coatomer WD associated region"
FT /evidence="ECO:0000259|Pfam:PF04053"
FT DOMAIN 833..1219
FT /note="Coatomer alpha subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06957"
SQ SEQUENCE 1221 AA; 135912 MW; 5D223ABC64C99AF4 CRC64;
MSSSPSMLTK FESKSSRAKG IAFHPKRPWI LVSLHSSTIQ LWDYRMGTLI DRFEEHDGPV
RGIDFHKTQP LFVSGGDDYK IKVWSYQTRR CLFTLNGHLD YVRTVFFHHE LPWIVSSSDD
QTIRIWNWQN RSLICTMTGH NHYTMCAQFH PKEDLIVSAS LDQSVRVWDI SGLRKKHSAP
TSMSFEDQLA RSNQNQADMF GNTDAVVKFV LEGHDRGVNW VAFHPTLPLI VSAGDDRLVK
LWRMSETKAW EVDTCRGHFQ NASACLFHPH QDLILSVGED KTIRVWDLNR RTSVQSFKRE
NDRFWVIAAH PEINLFAAGH DNGVMVFKLE RERPASSVYQ NNLFYITKEK HVRSYDFQKN
IESPSMLSLK KLGSAWVPPR TLSYNPAERS ILVTSPADSG TYELISLPRD ASGAVEPTDT
KRGSGNSAVF VARNRFAVFT QANQQIDIKD LSNSTTKTIK PPHGTTDIYF GGTGNLLLIT
PTNVVLYDIQ AKKNLAELAV NGVKYVVWSS DGLHVALLSK HNVTIATKNL EQVSTLHETI
RIKSATWDDT GVLLYSTLNH IKYSLMNGDN GIVRTLEHTV YLVRVKGRNV YCLDRAAKPK
ILQIDPTEYR FKLALVKRNY DEMLNIIKTS SLVGQSIISY LQKKGYPEIA LQFVQDPQTR
FELAIECGNL EVAVEMAKQL DRPKLWQRLS TEALAHGNHQ IVEMTYQKLR NFDKLSFLYL
ATGDQDKLKR MAKIAEHRGD MTARFQNALY LGDVQNRIEM FQEIDLYPLA YATAKANGLD
EQAQSILEAA GVTEDQINLP SIGGALAPAK PIVPTHKTNW PTRAASSTVF EKALMGEVEG
VSSDEPAANG YGDEDLLGDA EAPNAAAELG GGDDEDDVGG WDMGDDGDVE AEDEFVEVEG
AEAGAGSSEA DLWARNSPLA ADHVAAGSFE TAMQLLNRQI GAVNFAPLEE RFQEIYQATR
TFLPATPNMP SLVNYVRRTV DETDSRKILP IVPRDLESIL STDLTAGKQG LLKNKLEDGI
VAFKKLLHLL IVNVVASQAE LTEARRAINV AAQYIVAMSI ELERRALLQG ATDVAALSDD
DKKRALELSA YFTIPELEGP HRSIPLSAAM NFAHKNKQLN TALNFANALL DRTGNAKMKE
SAKRIKTVAE RNPADVIEID FDQFADFEIC AASHTPIYGG SPSSACPYDG AKYHAKYKGT
VCKVCEVCQI GAPASGLRLV G
//
