ID   A0A178AZF4_9PLEO        Unreviewed;       658 AA.
AC   A0A178AZF4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN   ORFNames=IQ06DRAFT_120061 {ECO:0000313|EMBL:OAL02772.1};
OS   Stagonospora sp. SRC1lsM3a.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Massarineae; Massarinaceae; Stagonospora.
OX   NCBI_TaxID=765868 {ECO:0000313|EMBL:OAL02772.1, ECO:0000313|Proteomes:UP000077206};
RN   [1] {ECO:0000313|EMBL:OAL02772.1, ECO:0000313|Proteomes:UP000077206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRC1lsM3a {ECO:0000313|EMBL:OAL02772.1,
RC   ECO:0000313|Proteomes:UP000077206};
RG   DOE Joint Genome Institute;
RA   Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA   Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT   "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT   ascomycete fungi.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR   EMBL; KV441709; OAL02772.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A178AZF4; -.
DR   STRING; 765868.A0A178AZF4; -.
DR   InParanoid; A0A178AZF4; -.
DR   OrthoDB; 1065060at2759; -.
DR   Proteomes; UP000077206; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF191; SODIUM_HYDROGEN EXCHANGER; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077206};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT   TRANSMEM        35..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        129..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        433..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..455
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          492..609
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  72021 MW;  A6CC0BCD92730178 CRC64;
     MASVVGWWAI GQMLKRDAVD ADPDEEPEAG QKEIFTSWAL SILIVLLIIA LFTSYILHTR
     KIQAVHETVL SIVAGMVVGL VLRLTAVSSV RDVVSFDYQM FFNLLLPPII LSAGYELHQG
     NFFRHIGAIL TFAFAGTFIS ALVLGIILFL WTRIPLDGFQ INFVEAMSVG ATLSATDPVT
     ILAIFDTYKV EPKLYTLIFG ESILNDAVAI VLFETAQKYK DGAESLGIVS LFEAFGIFFG
     VFFGSLFIGV MVGIGASLML KFTYVRRFPK TESCLIILIA YLTYFFSNAI HMSGIVSLLF
     CGICLKHYAY HNMSRRTQLS TKFVFQVTAQ LSENFIFIYL GLSLFTDDKL EYKPLFILIT
     VAGICAARWC AVFPLSKLIN AISRYRQRRR GEEVVEEIPW AHQAMIYWAG LRGAVGVALA
     AGLTGTAGDT LRATVLVVVV LTVIIFGGTT ARMLEILGIR TGVVEEIDSD DEFDIEVVNG
     GMYARNKGQA IGNTPRLNQN GFNLNNVNGQ EGTYSSGSFA HNSPPIRPNG FPLRRNSSRQ
     RRSDGQDQGL LSPHDSGSAD EDDNDLDLPP NARRSPNRNP SPLGLSGEPA LYPTSGHRAE
     EPTAAEGSSR IATATGAVKH LFNEISHDPA NAFKQIDDGF LKPHLLLDPG KGPGPNNV
//