ID A0A178EAI4_9PLEO Unreviewed; 568 AA.
AC A0A178EAI4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Delta 8-(E)-sphingolipid desaturase {ECO:0000256|ARBA:ARBA00016939};
DE EC=1.14.19.18 {ECO:0000256|ARBA:ARBA00012019};
GN ORFNames=IQ07DRAFT_672393 {ECO:0000313|EMBL:OAL52103.1};
OS Pyrenochaeta sp. DS3sAY3a.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Cucurbitariaceae;
OC Pyrenochaeta.
OX NCBI_TaxID=765867 {ECO:0000313|EMBL:OAL52103.1, ECO:0000313|Proteomes:UP000077535};
RN [1] {ECO:0000313|EMBL:OAL52103.1, ECO:0000313|Proteomes:UP000077535}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS3sAY3a {ECO:0000313|EMBL:OAL52103.1,
RC ECO:0000313|Proteomes:UP000077535};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
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DR EMBL; KV441642; OAL52103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A178EAI4; -.
DR STRING; 765867.A0A178EAI4; -.
DR InParanoid; A0A178EAI4; -.
DR OrthoDB; 294339at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000077535; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF30; DELTA 8-(E)-SPHINGOLIPID DESATURASE; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Reference proteome {ECO:0000313|Proteomes:UP000077535};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT DOMAIN 9..84
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 110..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 65085 MW; CC07C0D53F3736A0 CRC64;
MDAQAPRKAK ILSRRDIEAQ IAEGRAIVIV DNKVLKVDAW LPYHPGGDKA IRHMIGRDAT
DEVTRFHSSQ TLELMTRYQI GRVNGRWTNF TPPIQGGKFR TRAELDCLSE EQYVESSSSS
SERDGSSSSS SAEHSPVFEP ADQSTTSLRQ RNAKIPRASS TSSIPSVDIG DSVASPKMSV
LDRRTQQELD FDRSKYPALD PATQDRITQK YRELQKRIKA EGLYDCNYTS YGIEGLRYGT
FFCAFLYLLT NGWYIPSAVP LACLWHQLTF TVHDAGHMGI THDFTTDTTI AMFIASFMGG
LSACWWKYNH NVHHLVTNDP EHDPDIQYIP FFAVTQRFLQ SLTTTYYERV MEYDALAKVM
IRIQHYTYYP IMCVARFNLY RLSLEHLILG KGPKKGPAWW HRYFEITGMA VFWTWYGYGV
VYKSIPDNWS RFWFVLISHA LTSPLHVQIT LSHFAMSTAD LGTHESFAQK MLRTTMDVDC
PQWLDFFHGG LQFQAIHHLY PRIPRHRLRE TQKLVQGFCN EVDIPYALYG FVDGNKQVIG
RLADVARQAA IFAECQRTLA LEGDYGLH
//
