ID A0A178EZ24_TRIRU Unreviewed; 909 AA.
AC A0A178EZ24;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=A7C99_3556 {ECO:0000313|EMBL:OAL65076.1};
OS Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=5551 {ECO:0000313|EMBL:OAL65076.1, ECO:0000313|Proteomes:UP000243015};
RN [1] {ECO:0000313|EMBL:OAL65076.1, ECO:0000313|Proteomes:UP000243015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCC(F)T1i {ECO:0000313|Proteomes:UP000243015};
RA Zhan P., Tao Y., Liu W.;
RT "Genome sequencing of Trichophyton rubrum CMCC(F)T1i isolated from hair.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAL65076.1}.
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DR EMBL; LHPM01000014; OAL65076.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A178EZ24; -.
DR VEuPathDB; FungiDB:TERG_06668; -.
DR OMA; PKRYYAH; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000243015; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000243015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 55..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..205
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 228..423
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 435..708
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 811..901
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
SQ SEQUENCE 909 AA; 102530 MW; 03A09DCBC600DC2B CRC64;
MEMSSEDLVA MSALIGRGVL DPSNDPNIGS ARGSNKSSTS DALQTVGITA STSGMALLST
FLPAFILAVI GFLIFLICRR TQRRFYSPRS YLGHIHDHER SPELPYGFVN WIGDFIRLSD
SHVLRNSSLD GYLFLRFLKK MSLLSFIGCC ITWPILMPIN ITGGAGNTQL DLLTFSNVVN
PKRYYAHTIV SWIFFGVVFL MVCRESIFYA ALRQAYLLSP LYADRISSRT VLFMSVPQSY
QNKAKLSKIF GDSVKRVWTS EDTSKLATLV RKRDRLAYSL EDAETRYVKA AHAARLKVLK
KQGRDPEVSL EQATVKQSSN ESDLDQAPWL LNVKCPSRLA HYVFGEKVDI IEDLRSRLAT
LIPEVNELQQ EHRVGEAKTV GGVFVEFTTQ REAQIAYQTL SHHHPSQMTP RFIGIPPHQV
LWPALRYSWY QRIVRKFAVQ GFITVMIIFW SIPSALIGSI SNITYLTNLL KFLKFVNELP
SFIKGIISGL LPAAGLAILM AAVPWIMRWC ARQSGVPSTA KAELFTQNAH FCFQVVQVFL
VTTITSAASA ATSQIIKNPL SAKDLLAKNL PKATNFYISY FLFQGLMLSS GAVVQVIAFL
LFKFFRAFFD STPRKLYSRW AALTGVWWGT VFPVFTNMAV IAITYSCIAP LVLGFSALGL
YLVYQAYRYN LLFVYEPVVD TKGLVYPRAL QQVLTGVYLA EVCMFGLFAI RAAIGPMVLM
GMFTAFTALC HISLNEALAP LLSALPHTLN NEDDWTCTTP SDFEKPEFLS RTMTSGKEFL
PRRQSTLTLA EITTAPDSIW DKFENFRWWL FHPSIYANYA ALREKIRQDP SIPYDEHISD
NAYYPSCVYS RPPLLWIPRD AGGVSRQEVE LTSTIIPMTD NEAHLDEKNK VVWDKVGMKP
PIWEEKVFY
//
