ID A0A178M5A7_9PROT Unreviewed; 1156 AA.
AC A0A178M5A7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=A6A04_08650 {ECO:0000313|EMBL:OAN43942.1};
OS Paramagnetospirillum marisnigri.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Magnetospirillaceae; Paramagnetospirillum.
OX NCBI_TaxID=1285242 {ECO:0000313|EMBL:OAN43942.1, ECO:0000313|Proteomes:UP000078428};
RN [1] {ECO:0000313|EMBL:OAN43942.1, ECO:0000313|Proteomes:UP000078428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP-1 {ECO:0000313|EMBL:OAN43942.1,
RC ECO:0000313|Proteomes:UP000078428};
RA Koziaeva V., Dziuba M.V., Ivanov T.M., Kuznetsov B., Grouzdev D.S.;
RT "Draft genome sequence of freshwater magnetotactic bacteria
RT Magnetospirillum marisnigri SP-1 and Magnetospirillum moscoviense BB-1.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAN43942.1}.
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DR EMBL; LWQT01000120; OAN43942.1; -; Genomic_DNA.
DR RefSeq; WP_068495738.1; NZ_LWQT01000120.1.
DR AlphaFoldDB; A0A178M5A7; -.
DR STRING; 1285242.A6A04_08650; -.
DR Proteomes; UP000078428; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000078428}.
FT DOMAIN 625..786
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 807..961
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1156 AA; 125206 MW; 1C2D7CDFBFFDA2FF CRC64;
MKRLDDLISQ AGSFAVAGAP EGRDALLVAE LAASAGDILL VARDDGRMAR LAEALAFFAP
DLPVLEFPAW DCVPYDRVSP NVDVVARRID TLARLADGGG QGPRLILTTV AALAQRVPPR
EGLAKATLNA RPGASLSIER LVEFLHRSGY VRADTVMEPG EFAVRGGIVD LFPPGAAEPM
RLDFFGDEIE AVRSFDPMSQ RTTGPVAGFS CRPVSEVGLD DASIARFRAA YRELFGVVQG
ADPLYESISE GVKFTGMEHW LPLFHDGLDT LFAYCPEAAV VLDHQADEAL AARHALVLEY
YDARVSMGGS GLAESGMVYH PVPPPKLYLE RDEWDRLLAV RPVLRLSPFD AMDGGAAFDA
GGRLGRDFAD VRARPGVNLY DELRQHAEEQ AKTGRRVVVA AWTIGSRDRL AGLLKDHGLK
GGETADSWTD VQALPKGKVA LAVLGLDHGF VTPDLALITE QDILGDRLAR PARKKKKGAQ
FIAEASALSE GDLVVHVEHG IGRYDGLVAL QVAGAPHDCL RVLYDGGDKL FVPVENIEVL
TRFGSDQSGV ALDKLGGTAW QARKAKLKKR IRDIADQLIG IAAQRQLRQG ETLTPAEGLY
DEFCARFPWA ETDDQMRAIE DCVADLASGR PMDRLICGDV GFGKTEVALR AAFVAALQGL
QVAVVVPTTL LARQHFRTFT ERFKGLPVRV EQLSRLVTAK TATAVKAGVA EGSVDIVVGT
HALLAKGIGF KRLGLLIIDE EQHFGVAHKE RLKQLKSDVH VLTLTATPIP RTLQMALSGV
KEMSVIATPP VDRLAVRTFV LPYDPVVLRE AILRERYRGG QVFYVCPRLA DIDRVAERLA
KLVPEVKTAV AHGRLAPADL EEVMVAFGDK QYDVLLSTNI VESGLDMPSV NTLIIHRADM
FGLGQLYQLR GRVGRGKTRG YAYFTLPNDK LLSKAAEKRL QVMQALDTLG AGFQLASHDL
DIRGAGNLLG EEQSGHIREV GIELYQQLLE EAVAAAKGGT GAEAAEEWSP QIAIGSPVLI
PDTYVADLSV RLGLYRRIAA LDTSEEIEAL AAELIDRFGK LPPEVENLLE VIAIKALCKQ
AGIEKVDSGP KGAVVTFRGN VFANPVGLVQ FISRAGGSCK LRPDHKLVFL RNWEDPRDRV
AGLRKVVGKM AELALA
//
