ID A0A178ZIE7_9EURO Unreviewed; 409 AA.
AC A0A178ZIE7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 22.
DE RecName: Full=Protein phosphatase methylesterase 1 {ECO:0000256|ARBA:ARBA00020672, ECO:0000256|PIRNR:PIRNR022950};
DE Short=PME-1 {ECO:0000256|PIRNR:PIRNR022950};
DE EC=3.1.1.- {ECO:0000256|PIRNR:PIRNR022950};
GN ORFNames=AYL99_06856 {ECO:0000313|EMBL:OAP59558.1};
OS Fonsecaea erecta.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1367422 {ECO:0000313|EMBL:OAP59558.1, ECO:0000313|Proteomes:UP000078343};
RN [1] {ECO:0000313|EMBL:OAP59558.1, ECO:0000313|Proteomes:UP000078343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 125763 {ECO:0000313|EMBL:OAP59558.1,
RC ECO:0000313|Proteomes:UP000078343};
RA Weiss V.A., Vicente V.A., Raittz R.T., Moreno L.F., De Souza E.M.,
RA Pedrosa F.O., Steffens M.B., Faoro H., Tadra-Sfeir M.Z., Najafzadeh M.J.,
RA Felipe M.S., Teixeira M., Sun J., Xi L., Gomes R., De Azevedo C.M.,
RA Salgado C.G., Da Silva M.B., Nascimento M.F., Queiroz-Telles F.,
RA Attili D.S., Gorbushina A.;
RT "Draft genome of Fonsecaea erecta CBS 125763.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Demethylates proteins that have been reversibly
CC carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.
CC {ECO:0000256|ARBA:ARBA00024741}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester +
CC H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) +
CC methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-
CC COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790,
CC ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000906};
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00008645, ECO:0000256|PIRNR:PIRNR022950}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAP59558.1}.
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DR EMBL; LVYI01000005; OAP59558.1; -; Genomic_DNA.
DR RefSeq; XP_018692925.1; XM_018838365.1.
DR AlphaFoldDB; A0A178ZIE7; -.
DR STRING; 1367422.A0A178ZIE7; -.
DR GeneID; 30011024; -.
DR OrthoDB; 169198at2759; -.
DR Proteomes; UP000078343; Unassembled WGS sequence.
DR GO; GO:0051723; F:protein methylesterase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR016812; PPase_methylesterase_euk.
DR PANTHER; PTHR14189:SF0; PROTEIN PHOSPHATASE METHYLESTERASE 1; 1.
DR PANTHER; PTHR14189; PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR PIRSF; PIRSF022950; PPase_methylesterase_euk; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR022950};
KW Reference proteome {ECO:0000313|Proteomes:UP000078343};
KW Serine esterase {ECO:0000256|PIRNR:PIRNR022950}.
FT DOMAIN 119..374
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF12697"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 208
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
FT ACT_SITE 234
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
FT ACT_SITE 362
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
SQ SEQUENCE 409 AA; 44397 MW; 073D6E19AD84D830 CRC64;
MSHLQKSFAR ARLSHLPPEP PTPVDEQEEE GDDLTALRPG SPNDSSSSAS STSSTGTIVP
SPSRNLFEKP RSAAIKSRNA PLPWDDFFTQ DLAFDQKTPS ETIHHHVYLT PPSASGPLIV
THHGAGSSGL SFAAFTVEVL KILPNAGVLS LDARGHGQTT TTTLSGSSPP SQDLSLTTLA
EDVAFVVNAV KAYMKWSTLP DIVLIGHSLG GAVVTEVAHE RLLGNTLLAY GVLDVVEGSA
MDALKSMDTY LSTRPKSFPS LASGIEWHTK SRTIRNTTSA RVSVPSLLQE SKTTKGTWYW
RTDLAATKPF WEDWFIGLSK KFLESRGGKL LLLAGTDRLD KELTIGQMQG KYQLQVFPEA
GHFIQEDQPA KTAQVVADFY KRNDRTGLVL PPKVDDLIRQ GKLKPAGMK
//
