ID A0A178ZS74_9EURO Unreviewed; 1154 AA.
AC A0A178ZS74;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AYL99_04727 {ECO:0000313|EMBL:OAP62522.1};
OS Fonsecaea erecta.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1367422 {ECO:0000313|EMBL:OAP62522.1, ECO:0000313|Proteomes:UP000078343};
RN [1] {ECO:0000313|EMBL:OAP62522.1, ECO:0000313|Proteomes:UP000078343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 125763 {ECO:0000313|EMBL:OAP62522.1,
RC ECO:0000313|Proteomes:UP000078343};
RA Weiss V.A., Vicente V.A., Raittz R.T., Moreno L.F., De Souza E.M.,
RA Pedrosa F.O., Steffens M.B., Faoro H., Tadra-Sfeir M.Z., Najafzadeh M.J.,
RA Felipe M.S., Teixeira M., Sun J., Xi L., Gomes R., De Azevedo C.M.,
RA Salgado C.G., Da Silva M.B., Nascimento M.F., Queiroz-Telles F.,
RA Attili D.S., Gorbushina A.;
RT "Draft genome of Fonsecaea erecta CBS 125763.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAP62522.1}.
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DR EMBL; LVYI01000003; OAP62522.1; -; Genomic_DNA.
DR RefSeq; XP_018695889.1; XM_018836239.1.
DR AlphaFoldDB; A0A178ZS74; -.
DR STRING; 1367422.A0A178ZS74; -.
DR GeneID; 30008895; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000078343; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000078343};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 63..129
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 693..813
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 873..1116
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 127410 MW; 2B96CF162151C147 CRC64;
MREPQPSGIY VAPLRIRKNS DDDGGDDENH GPSVKTKDSV LPNTNPRPAS IESLDDMASS
RARFHNYLRA LYPFQPSSPH SSTTVTLPLN AGDIILVHSV HINGWADGTL LETGARGWLP
TNYCEGYDYA AMRPILKALT EFWDLVRCAS DSNLGLFRNQ DYMRGLVAGV RALLERSNCL
TRDCSLVKKH DAIRRTRKNL LSDLALLVRA AKELQQVVMG HSASKDTLDI RLDDMLLKAF
RIVTRAVLFY DVWTEQADAS PGAVTRPPDS SSESVAIMQS QHSIKSQATV RRQASTSVTT
KAAGTTVLSK HGSHSSTGNP THVRRHSSIT HRMSYSRSTS QKNSNLISEF LNRSYDEFLT
VLASFLGSHM QSRSSSELLL TTQNAVRACR QLFAVVETVI DRDYSTSRPL VQAKDSMYDA
ITELVHAARQ VFKPIRSMDD DLIYSPDEAH SLVQAATACV SAAGRCVSRT KATLEEIGDF
EIENLSYLLG RNSGGSSTPE PANFERPPSE RLTTSSAVTS AKAKSTDRLE ERPRIIINQG
LLTPPLSHTT AESPSTASGS VPPTPKDDVV VEIIRSSPLP SASLAHQKIS SSSPVSSQST
EVRHHRKSGA HAVGGSTSSD SSFERLERRS NPSNLSSAST RVTSVQEDLS HSLKPPVSRP
SHDGGAREPL DDDEDAEAEI LVHTYSQELV FNREGIIVGG TLNALVERLT APDSAPDVSF
FTTIYLTFRL FATPVTFARA LIYRFEYVGD NLSIAGPVRL RVYNVLKGWM ESHWRHDCDD
TALPVIVGFA RESLINVLPM AGKRILELAE KVATSHAPIV PRVLSAIGKT STSTAAYVDP
STPLPHPVIS KSQLTALRAW KMGGPSVSIL DFDPLELARQ ITLKTSKIFC SILPEELLGT
EWTKRSSSLA VNVRAMSTLS TDISNLVSDS VLQLEEPKKR AAIVKQWVKI ANKCLDLRNF
DTVMAIVCAL DSTNIKRMKR TWECVPHKTK TVFDEMCKIV DVARNYAVLR QRIQSQLPPC
LPFIGVYLTD LTMVDSANPS TRPLSTDRGE ASVINLDKHM KTAKIISELQ KFQIPYRFAE
VSELQTWMQD QLIRVRSAGD GSFQLHYRRS LILEPREPSR SPNPETGTGK DRERFDFFTW
AHLVPKEKSV SVSS
//
