ID A0A179DFU0_9SPHI Unreviewed; 349 AA.
AC A0A179DFU0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:OAQ39672.1};
GN ORFNames=A5893_08800 {ECO:0000313|EMBL:OAQ39672.1};
OS Pedobacter psychrophilus.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=1826909 {ECO:0000313|EMBL:OAQ39672.1, ECO:0000313|Proteomes:UP000078459};
RN [1] {ECO:0000313|EMBL:OAQ39672.1, ECO:0000313|Proteomes:UP000078459}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 8644 {ECO:0000313|EMBL:OAQ39672.1,
RC ECO:0000313|Proteomes:UP000078459};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAQ39672.1, ECO:0000313|Proteomes:UP000078459}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 8644 {ECO:0000313|EMBL:OAQ39672.1,
RC ECO:0000313|Proteomes:UP000078459};
RA Svec P.;
RT "Pedobacter psychrophilus sp. nov., isolated from Antarctic fragmentary
RT rock.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ39672.1}.
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DR EMBL; LWHJ01000027; OAQ39672.1; -; Genomic_DNA.
DR RefSeq; WP_068822291.1; NZ_LWHJ01000027.1.
DR AlphaFoldDB; A0A179DFU0; -.
DR STRING; 1826909.A5893_08800; -.
DR OrthoDB; 9806940at2; -.
DR Proteomes; UP000078459; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000078459};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 17..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 349 AA; 38286 MW; 35598E88C4C3D505 CRC64;
MTQVKAYAAE KADKPVGPFK IDRRDVGEND VEIEILFCGV CHSDIHTARN EWGGTMYPVV
PGHEIVGKVS KIGDKVKNHK VGDTVGVGCF VDSCGHCDNC EDDLEQYCEN GNSQTYNSKL
QDKKTITYGG YSTHIVVTEK FVLKVSDKLD LAGVAPLLCA GITTYSPLKH WNCKKGDKVA
VVGLGGLGHM AVKLASSMGA EVTMLSRSPE KEKDAEELGA HHFMLTTEKE NMEKMANSFD
LIINTVSAKH DYNEYLALLR TNGTMVLLGV PPEALPVAAP NLIFGRRSLV GSLVGGIKET
QEMLDYCAEH NIVSDIEMIN IDKINEAYER TLKGDVHYRF VIDMASLKN
//
