ID A0A179ER05_ENTTH Unreviewed; 865 AA.
AC A0A179ER05;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN Name=aad {ECO:0000313|EMBL:GEK37002.1};
GN ORFNames=A6E74_06335 {ECO:0000313|EMBL:OAQ55677.1}, CK496_00995
GN {ECO:0000313|EMBL:ASZ06575.1}, ETH01_12890
GN {ECO:0000313|EMBL:GEK37002.1};
OS Enterococcus thailandicus.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=417368 {ECO:0000313|EMBL:OAQ55677.1, ECO:0000313|Proteomes:UP000078516};
RN [1] {ECO:0000313|EMBL:OAQ55677.1, ECO:0000313|Proteomes:UP000078516}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0711D 46 {ECO:0000313|EMBL:OAQ55677.1,
RC ECO:0000313|Proteomes:UP000078516};
RA Beukers A.G., Zaheer R., Goji N., Cook S.R., Amoako K., Chaves A.V.,
RA Ward M.P., Mcallister T.A.;
RT "Draft genome of an Enterococcus thailandicus strain isolated from bovine
RT feces.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ASZ06575.1, ECO:0000313|Proteomes:UP000217197}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=a523 {ECO:0000313|Proteomes:UP000217197}, and A523
RC {ECO:0000313|EMBL:ASZ06575.1};
RA Ybazeta G., Douglas L., Graham J., Fraleigh N., Murad Y., Perez J.,
RA Diaz-Mitoma F., Nokhbeh R.;
RT "Whole genome sequencing and hybrid de novo assembly of Enterococcus
RT thailandicus a523.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:GEK37002.1, ECO:0000313|Proteomes:UP000321361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101867 {ECO:0000313|EMBL:GEK37002.1,
RC ECO:0000313|Proteomes:UP000321361};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Enterococcus thailandicus NBRC 101867.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
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DR EMBL; CP023074; ASZ06575.1; -; Genomic_DNA.
DR EMBL; BJUG01000006; GEK37002.1; -; Genomic_DNA.
DR EMBL; LWMN01000012; OAQ55677.1; -; Genomic_DNA.
DR RefSeq; WP_067483323.1; NZ_LWMN01000012.1.
DR AlphaFoldDB; A0A179ER05; -.
DR GeneID; 77486210; -.
DR KEGG; eth:CK496_00995; -.
DR PATRIC; fig|417368.6.peg.2155; -.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000078516; Unassembled WGS sequence.
DR Proteomes; UP000217197; Chromosome.
DR Proteomes; UP000321361; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000078516}.
FT DOMAIN 17..410
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 465..851
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 865 AA; 94414 MW; A6E44F70CB2DE241 CRC64;
MAKTLEKEQV KTIDVQAMID DLATKANVAL KEMEDFDQAK VDHIVHEMAM AALDQHMPLA
KMAVEETGRG IYEDKAIKNM YASEYIWNNI KHDKTVGVIN EDVQKGLIEI AEPVGVVCGV
TPTTNPTSTT IFKSMIALKT RNPIVFAFHP SAQKSSAEAA RVVRDAAIAA GAPENCIQWI
EHPSIDATSM LMNHPGIAIV LATGGAGMVK SAYSTGKPAL GVGPGNVPAY IEKTAKVKRA
VNDLIVSKTF DNGMICASEQ AVIVDKEIYA AVKAEFQAHQ VYFVKPSELA KLEDAVMNEG
KYAVNPAIVG HSAMEIAKLA GIKVPEGTKM LIAELEGVGA DYPLSREKLS PVLAMVKANN
TDHAFELCEG MLNLGGLGHT AVIHSENEDL HVKFGLRMKA CRILVNTPSA EGGIGNIYNE
MIPSLTLGCG SYGKNSVSRN VSAVNLINVK TVAKRRNNMQ WFKLPPKIFF EKNSLLYLEK
MENVERVMIV CDPGMVQFGY CDTVREVLAR RKNDVKIEVF SDVEPNPSTD TVYAGTKLMA
DFKPDTVIAL GGGSAMDAAK GMWMFYEHPD TSFFGAKQKF LDIRKRTYKI AKPEKTQFVC
IPTTSGTGSE VTPFAVITDS DTHVKYPLAD YALTPDVAIV DPQFVMSVPA SVTADTGMDV
LTHAIESYVS VMASDYTRGL SLQAIKLVFD YLEKSVKTPD MESREKMHNA STMAGMAFAN
AFLGICHSIA HKIGGEYGIP HGRTNAILLP HIIRYNAKDP QKHAMFPKYD YFRADTDYAD
IAKFLGLKGE TTAELVDALA KAVYELGQNV GIDMNLKAQG VTQETLDTTV DRMAELAYED
QCTTANPKEP LISELKQIII DAYKA
//
