ID A0A179EYV7_METCM Unreviewed; 355 AA.
AC A0A179EYV7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=NADP-dependent leukotriene B4 12-hydroxydehydrogenase {ECO:0000313|EMBL:OAQ58385.1};
GN ORFNames=VFPPC_10896 {ECO:0000313|EMBL:OAQ58385.1};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ58385.1, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ58385.1, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ58385.1};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ58385.1}.
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DR EMBL; LSBJ02000002; OAQ58385.1; -; Genomic_DNA.
DR RefSeq; XP_018136556.1; XM_018289192.1.
DR AlphaFoldDB; A0A179EYV7; -.
DR GeneID; 28853186; -.
DR KEGG; pchm:VFPPC_10896; -.
DR OrthoDB; 179761at2759; -.
DR Proteomes; UP000078397; Chromosome 2.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05288; PGDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR041694; ADH_N_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43205:SF42; ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530); 1.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR Pfam; PF16884; ADH_N_2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000078397}.
FT DOMAIN 21..343
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 355 AA; 38088 MW; 1C8E0F9CFBB75582 CRC64;
MKQDNLSVVL AERPTAEIVP GQTFHKKTTP IPSPADLKDG EILVETLIWA LETTANDKSV
CNVEDTRSYL PPVKIGAVMR GATAARVIAS KSKRAAAGDY VSAMSGWTEY AILGEGQFEP
ASSFPGLNPN EPQDILSVLG LTGATAWWGM TQIGDPKPGE LVVVSGAAGA TGSVAGQIAK
IKGATVVGIC GSDTKCSWLV DELGFDIALN YKDPDFREKF KSATKNYIDV YFDNVGGDIL
DMCLARAKEH SRFVMCGGIS QYNSANPVGP KNISKVITMR IKMQGFIVFD HQSRIPEIRK
ELSQWLAEGK LKKTETIIKG GLASAEQALV DLYKGANQGK LLVEVKNPAT PAIKL
//
