ID A0A179F004_METCM Unreviewed; 1039 AA.
AC A0A179F004;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VFPPC_10306 {ECO:0000313|EMBL:OAQ58590.1};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ58590.1, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ58590.1, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ58590.1};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ58590.1}.
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DR EMBL; LSBJ02000010; OAQ58590.1; -; Genomic_DNA.
DR RefSeq; XP_018136717.1; XM_018288699.1.
DR AlphaFoldDB; A0A179F004; -.
DR GeneID; 28852693; -.
DR KEGG; pchm:VFPPC_10306; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000078397; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078397};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..193
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 217..386
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 397..683
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 869..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1039 AA; 116095 MW; 1749C8E55551E9D9 CRC64;
MAALHTLLGR DDPNHKDAGQ ELIDLLKNPF VADKLATASV YSALATSLGV TAFIAICFSF
IRPYHQAIYA PKSKHADEKH APPPIGKEPW AWITPLINTK ELTLMNQIGM DATIFLRFVR
MCRNMFLVLA LVGVGILVPV NLTNYKEFGK DNKPDTTEWM LRITPRNVFG SPHWALVVVG
YLFNIIVIGF LWWNYRKILH LRRLYFESDE YQNSLHARTL MLFDIPRQGC SDEGIARIID
SVVPNSSFAR TVVARNVKDL PELIEEHDKT VRKLEKVLAK YLKDPQNLPA GRPTCKASKK
DRSFDTYPSG QRLDAIDYLT QRIRDLEIEI KEVRASVDRR STMPYGFASY AEIAEAHSIA
YACRKKKPHG TTVRLAPKPT DVIWRNMPLS SATRSRRRWI NNLWIAVLTL LWVAPNAMIA
IFLVNLSNLG KVWKGFQDSL VAHTTIWGIV QGIASPALTS LVYLVLPMIF RRLSIKAGDQ
TKTGRERHVL GKLYAFFVFN NLVVFSFFGV LWSFIAGVIK ATEGENGSKK DAWSAIVEGE
LAQNIVIAFC NNSIFWVTYL LQRQLGAAVD LAQIWPLIVA FFQKKFSSPT PRELIELTAP
PPFEYANYYT YFLFYSTVTL CFGTIQPLCL LATAMYFSID CYLKKYLILY RFVTKTESGG
LFWRVVFNRM ILGAILANGV VLLTTWARGD GTHFQFYAVC PLPFIMIAFK IYCTRSFDDK
IRYYSIQHTA QHPEHGMQGD SRSRSDKLAS RFGHPALYKP LITPMVHQKA QNLLPSVYRG
RLTDGRDNDG ADLVTVSGYS DMYALDSMKG GKPGKAANAV PGFEYVSDAQ MDFQYYKNRA
EFTEEHGGGE MYGKGSDIMR TGTPGSFDDM GSNHSLSRPA SPMMSGVGGP GQPPRRVMTN
MSMADTSYSP YRQDTGYAPP SDPVSRGHTP LYSHDNGSSS GLVRNAAAMA GPPGYNSRDG
SVDRGRMTPT RIHSPAPQRV GSPQVSHSPA PGPSIGAMGG GPQGYSGLQQ QQDDADPMQY
NYFRSGSGNR PPRQPGQGW
//
