ID   A0A179F320_PURLI        Unreviewed;      1083 AA.
AC   A0A179F320;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Endonuclease/reverse transcriptase {ECO:0000313|EMBL:OAQ59771.1};
GN   ORFNames=VFPFJ_11565 {ECO:0000313|EMBL:OAQ59771.1};
OS   Purpureocillium lilacinum (Paecilomyces lilacinus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX   NCBI_TaxID=33203 {ECO:0000313|EMBL:OAQ59771.1, ECO:0000313|Proteomes:UP000078340};
RN   [1] {ECO:0000313|EMBL:OAQ59771.1, ECO:0000313|Proteomes:UP000078340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PLFJ-1 {ECO:0000313|EMBL:OAQ59771.1};
RA   Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yin W., Xie B.;
RT   "Biosynthesis of antibiotic leucinostatins and their inhibition on
RT   Phytophthora in bio-control Purpureocillium lilacinum.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAQ59771.1}.
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DR   EMBL; LSBI01000048; OAQ59771.1; -; Genomic_DNA.
DR   RefSeq; XP_018172788.1; XM_018328632.1.
DR   AlphaFoldDB; A0A179F320; -.
DR   STRING; 33203.A0A179F320; -.
DR   GeneID; 28893681; -.
DR   KEGG; plj:VFPFJ_11565; -.
DR   OMA; QTHRDEN; -.
DR   OrthoDB; 2695555at2759; -.
DR   Proteomes; UP000078340; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000313|EMBL:OAQ59771.1};
KW   Hydrolase {ECO:0000313|EMBL:OAQ59771.1};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nuclease {ECO:0000313|EMBL:OAQ59771.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:OAQ59771.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000078340};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:OAQ59771.1};
KW   Transferase {ECO:0000313|EMBL:OAQ59771.1}.
FT   DOMAIN          387..656
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          875..1006
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   1083 AA;  120660 MW;  C1D1907AE247296A CRC64;
     MTYVRRRPGL TADQRRPVTT RDILWLTINN TTIVNCYRQP DFDGALDILL AWSPPSRCLV
     AGDFNAKHYS WQTGRLDGRG DDIAHWAAES RLSLLNPTDV PTNPHGNTID LAFSNIPLSE
     AVVEDHLATS SDHFTLSIAL PEVGVAPILP GKVRVTTDDE IKRFVDLVQY GSADIPAPTT
     TTDDLDALAS ALVRLLQAAA KVAGRPVRKQ GRSAPWWTEE CRLAAAEYRA IRRVYPLGFC
     REVQLAKKDF QKVVRRAKRL YWRKLIDGFN DSASVFKAVR WLKSPGAFQP PPLEVDGEVH
     ETQLDKANAL RRATLERRTS EDDIADPWVP VAAARAIPFS QDVLLAEVRD ATIRTGNTSP
     GSDNITVNML KAAWHIIGEH VRRLYEGCLR LGHHPQPFRE AEVVMIAKPG RRNLSTPRAW
     RPTSLLSCLS KGLERLIARR LAWASIHYGV LHPQQAGALP KRSAVDLVAA LVHDIEEAFA
     RGLVATLVTM DIQGAFDTVL RNRLILRLRQ QGWPEHLARW AGSFMSDRSA CVRYQDITTP
     SSPLQCGLPQ GSPVSPILFL LYTEPIYRLG NPKGRFGYAD DTGILCVGNS LETTADRASR
     YVSELVTWGA ANGISFDPAK TEVMHFCRTK PKVSPPIFHE GERRPEKAMR WLGIWLDSTL
     TFKTHVEKWT AKAQAVAHHL RGLANTKHGP LPSAMQRAVR ACVEPVLLHG AEAWYPGLSS
     PRWSQPRKEG SSRIQQLLRK MNKSLHNSMR AVLPVWRTTP IAALHRESGI PPIAQLLETR
     RMRFAARLKR VDEAHPLAKR TLQPNPPTIH RSIKLKYQIP REAFRTRLRR SDQLLPRSTR
     PLLLPRRFDE HATPLQTAPK DESAKDLLEW LRSIPRETLI VYSDGSLSTE RAAGYGYVIH
     RNGLTLTSGS GRLGPAEVFD AEAKGALEGL RAALNLPGPR RIFVCLDNLA VANCLRGMPA
     DSSQDVFLEF QALTTTHGAT EVRWIPGHTN ITGNEQADAS AKAATSLPEP ADALPTLAHL
     RRTARQQSRD AFEAWWDASA PDQYKPLHLK PTTGCPPELE LPRPWSTTCL RHGPVTETLP
     TTT
//