ID A0A179FB81_METCM Unreviewed; 726 AA.
AC A0A179FB81;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Acyl-CoA synthetase {ECO:0000313|EMBL:OAQ62677.1};
GN ORFNames=VFPPC_11125 {ECO:0000313|EMBL:OAQ62677.1};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ62677.1, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ62677.1, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ62677.1};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ62677.1}.
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DR EMBL; LSBJ02000006; OAQ62677.1; -; Genomic_DNA.
DR RefSeq; XP_018140257.1; XM_018289390.1.
DR AlphaFoldDB; A0A179FB81; -.
DR STRING; 1380566.A0A179FB81; -.
DR GeneID; 28853384; -.
DR KEGG; pchm:VFPPC_11125; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000078397; Chromosome 6.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000078397}.
FT DOMAIN 13..74
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 78..512
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 579..662
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 726 AA; 79797 MW; 585618E0F28261C8 CRC64;
MDPPLPVRSH LQDEMLLESL NNPEDFWARQ AEHLYWHKKP EATLRMSQRK LQTGEFHPTW
EWFSGGEIST CYNCLDRHVA AGNGDRVAIY YDSPATDTKE TYSYNNLLSE VETLAGALRQ
QNVRKGDVVM LYMPMIPAAL IGMLAVNRLG AIHAVVFGGF AASALAQRID SCKPVILLTA
SCGIVGNRPP IAYRPLVEEA ISLSSHKPGR VVVWEREQLP WRTKSVACGG TLSRWLQRLG
RFARLTSDNY ISWQGMVKRA KARGVKADCV AVNSNDPIYI IHTSGTTGTP KGVPRDAGGH
AVGLHLSISY IFNIHQGDVA FTASDIGWVV GHSYILYAPL LAGASTVLYE GKPVGTPDAS
AFWRVVAEYK VNTMFTAPTA LRAIKRDDPD NHFLSKIGEA GGLRSLKALF LAGERSEPSL
ISMYQGLLDK YGAPSSSHVI DNWWSTEAGS PITSRVLNPH AALDRDSSVR NYNPLRIKPG
SAGKPMPGFN IRVVDEQGDE VQRGTMGNIV LGLPLAPTAF RTLWVDEERF YHSYLKRFGG
KFMDTGDAGW IDDEGYVYVM SRNDDVLNVS AYRLSTGSIE QAISSHPLVA ECCVVGVPDE
LKGQLPFAFI TLSTASHPES ALPDARISLE IQSLVRKQVG AFASLGGIIQ GKGMIPKTRS
GKTLRRVLRE LVENAVYGEF AKVVIVPSTV EDAVAVDVAR VKIKEYFEKS GSKHRPIESR
ETRRTS
//
