ID A0A179FKC2_METCM Unreviewed; 893 AA.
AC A0A179FKC2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=VFPPC_14282 {ECO:0000313|EMBL:OAQ66065.1};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ66065.1, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ66065.1, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ66065.1};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ66065.1}.
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DR EMBL; LSBJ02000004; OAQ66065.1; -; Genomic_DNA.
DR RefSeq; XP_018143152.1; XM_018292051.1.
DR AlphaFoldDB; A0A179FKC2; -.
DR GeneID; 28856045; -.
DR KEGG; pchm:VFPPC_14282; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000078397; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078397};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 32..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..184
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 207..398
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 409..681
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 784..876
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 745..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 100069 MW; 03316B410550D1B1 CRC64;
MGNFISWINK NIPADQNNGS GQSDSTNKPQ SVWGMIDTLI PVLIVSAIYL VLFLIFRRSQ
RRFYAPRTYI GGKHERSPEM PSGWFNWFGA FWKIPDAYAL THQTLDAYLF LRYLKVCTII
SFVSLCITWP ILFPINATGK GGQSQLEILS YSNVSVDKSS NYFYAHALVA WAVYGFLMYM
ITRECIFYIN LRQAYLLTPH YAKRISARTV LFTAVPQDYL DEAKIRQMFN NAVKNVWIAG
NTKKLDEKVE ERDKVAMKLE SAEVKLIRAV NAARTKAMKK GGNTDETEQD TETANVISRW
LPDKKRPSHR LGPLGLVGKK VDTLEWCRSE LEKNIPEVEK AQLAWKQDGN FEKVGSLFVE
FHTQADAQAA FQVITHHHAL HMSPKAIGVK PQDVIWKNLS IPWWQLIVRR YAVYAIVAVL
IIFWAIPVGI VGIISQVSTL VKLPGLGWLN DIPEKILGVI SGLLPAVAIS ILMSLVPVIM
RALARVAGSK TNTEAELFTQ NAYFCFQVLQ VFLIRSITDA ASTAIVQIAG DPGQVFSILG
SALPTTSNFY ISYFIVQGLT IAIGVVTQVV GLFIFRILYK FLAGTPRAKY TKWTTLTAIL
WGSLLPVYTN IVVISIVYSV IAPLILFWST LGLFMFYLAY RYNLLFVSDT AVDTQGLIYP
RALKQLFTGI YLGEIVMIGM FAVVKSPGPA VLMAIFLVFT ILFHITMTRS LSPLLYGLPR
TLETEEAIIQ TRGADVDAEV DDKEISNGAG ATNGADGDTS AAKKTVPGGN DYGVEKKGNM
FSRFFKPWIF SDYATLRHMV PQEQNINFAQ LQEIGEANER NAYFPPSVNS QPPQLWIPRD
PLGVSKHEIA LTSKVIPISD KGAHLDEKNK VVWSEDLTNE EDLPPIHDEK VYY
//
