ID A0A179FNA6_METCM Unreviewed; 317 AA.
AC A0A179FNA6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2017, sequence version 2.
DT 22-FEB-2023, entry version 23.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN ORFNames=VFPPC_08167 {ECO:0000313|EMBL:OAQ66631.2};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ66631.2, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ66631.2, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ66631.2};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ66631.2}.
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DR EMBL; LSBJ02000004; OAQ66631.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A179FNA6; -.
DR STRING; 1380566.A0A179FNA6; -.
DR OrthoDB; 1472480at2759; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000078397; Chromosome 4.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000078397}.
FT DOMAIN 49..306
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 317 AA; 35372 MW; 790F5E9DA136D3EE CRC64;
MAAQSLGASA AHIAPRKVPV LLLKTKSTPS DAYEEILAGQ EHLNEPLDRS FDPRFVPVLL
HRFDNGAMQR VRSLLELNQI SNEPGRKYGG MIFTSQRAVE AFAKVANCEK GDAVNCLQNV
PIYSVGPATT RALRAIQAEP PLQIFGEHTG NGEALAAYIL EHYHGWYSDR EALPPLLFLV
GEQRRDIIPK TLMDQSLAHD RRILVDEEIV YGTGVMESFP RDFEEILYET RHEPERWIVV
FSPTGCADML RGLGLLNQHG DKVDLQRRDG KSYIATIGPT TRAHLMDQFG FEPDVCADSP
SPDGILDGIV KFTMRHI
//
